STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (418 aa)    
Predicted Functional Partners:
hemL
Similar to Escherichia coli glutamate-1-semialdehyde 2,1-aminomutase HemL or Gsa or PopC or b0154 SWALL:GSA_ECOLI (SWALL:P23893) (426 aa) fasta scores: E(): 5.1e-141, 85.21% id in 426 aa.
 
 0.987
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.980
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
     
 0.930
hemB
Similar to Pseudomonas aeruginosa delta-aminolevulinic acid dehydratase HemB or PA5243 SWALL:HEM2_PSEAE (SWALL:Q59643) (337 aa) fasta scores: E(): 5.1e-86, 71.69% id in 325 aa, and to Yersinia pestis delta-aminolevulinic acid dehydratase HemB SWALL:Q8ZAM5 (EMBL:AJ414158) (340 aa) fasta scores: E(): 6.8e-115, 90.29% id in 340 aa; Belongs to the ALAD family.
 
  
 0.873
nirE
Similar to Paracoccus denitrificans uroporphyrin-III C-methyltransferase NirE SWALL:NIRE_PARDE (SWALL:Q51701) (287 aa) fasta scores: E(): 2.3e-41, 49.6% id in 256 aa, and to Vibrio cholerae uroporphyrin-III C-methyltransferase vc2561 SWALL:Q9KP18 (EMBL:AE004324) (299 aa) fasta scores: E(): 1.6e-48, 58.15% id in 239 aa; Belongs to the precorrin methyltransferase family.
 
  
 0.841
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
  
  
 0.798
cysG2
Siroheme synthase [includes: uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
 
  
 0.793
cysG1
Siroheme synthase [includes: uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
 
  
 0.778
hemK
Protein methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
     
 0.736
sirB2
Putative membrane protein; Similar to Escherichia coli protein SirB2 or b1213 SWALL:SIB2_ECOLI (SWALL:Q46755) (130 aa) fasta scores: E(): 2.3e-16, 44.61% id in 130 aa, and to Salmonella typhimurium, and Salmonella typhi protein SirB2 or stm1774 or sty1899 SWALL:SIB2_SALTY (SWALL:Q9XCQ2) (129 aa) fasta scores: E(): 4.7e-20, 55% id in 120 aa.
       0.688
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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