STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
srfAPutative virulence effector protein; Similar to Salmonella typhimurium, and Salmonella typhi SrfA or sty1472 SWALL:Q9KIK0 (EMBL:AF231758) (399 aa) fasta scores: E(): 2.4e-16, 41.06% id in 431 aa, and to Yersinia pestis putative virulence factor y2121 SWALL:AAM85682 (EMBL:AE013815) (477 aa) fasta scores: E(): 4.2e-29, 51.02% id in 488 aa. (459 aa)    
Predicted Functional Partners:
srfB
Putative virulence effector protein; Similar to Salmonella typhimurium SrfB or stm1594 SWALL:Q9KIJ9 (EMBL:AF231758) (993 aa) fasta scores: E(): 0, 57.47% id in 997 aa, and to Yersinia pestis putative virulence factor ypo2290 SWALL:Q8ZE92 (EMBL:AJ414151) (1023 aa) fasta scores: E(): 2.1e-214, 73.8% id in 1027 aa.
     0.981
srfC
Putative virulence factor; Similar to Salmonella typhimurium SrfC or stm1595 SWALL:Q9KIJ8 (EMBL:AF231758) (714 aa) fasta scores: E(): 4.2e-23, 30.06% id in 795 aa, and to Yersinia pestis putative virulence factor y2123 SWALL:AAM85685 (EMBL:AE013815) (846 aa) fasta scores: E(): 2.9e-65, 55.12% id in 849 aa.
 
     0.946
macB
Macrolide-specific ABC-type efflux carrier; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.749
flk
Cell division protein; Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. Flk could inhibit FlgM secretion by acting as a braking system for the flagellar-associated type III secretion system.
  
     0.681
mtlR
Mannitol operon repressor; Similar to Escherichia coli, and Escherichia coli O6 mannitol operon repressor MtlR or b3601 or c4418 SWALL:MTLR_ECOLI (SWALL:P36563) (195 aa) fasta scores: E(): 2.6e-47, 74.15% id in 178 aa.
  
     0.655
ECA4366
Similar to Salmonella typhi hypothetical protein Sty4178 SWALL:Q8Z293 (EMBL:AL627281) (523 aa) fasta scores: E(): 3.7e-67, 44.09% id in 381 aa, and to Escherichia coli hypothetical protein yhjs or b3536 SWALL:YHJS_ECOLI (SWALL:P37657) (523 aa) fasta scores: E(): 1.6e-66, 44.97% id in 378 aa.
  
     0.648
wecH
Putative membrane protein; Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units.
  
     0.632
traF
Putative plasmid transfer protein; Similar to Shigella sonnei TraF protein SWALL:Q9Z4A1 (EMBL:AB021078) (400 aa) fasta scores: E(): 2.9e-81, 55% id in 400 aa, and to Salmonella typhimurium TraF protein SWALL:Q9R2H5 (EMBL:AB027308) (400 aa) fasta scores: E(): 3.4e-81, 54.75% id in 400 aa, and to Escherichia fergusonii TraF SWALL:Q8KR61 (EMBL:AY046057) (401 aa) fasta scores: E(): 1e-61, 44.52% id in 402 aa.
  
   
 0.623
ECA2264
Putative exported protein; Similar to Escherichia coli O6 hypothetical protein ydga or c2006 SWALL:AAN80466 (EMBL:AE016761) (502 aa) fasta scores: E(): 3.5e-65, 38.67% id in 512 aa, and to Shigella flexneri orf, conserved hypothetical protein ydga or sf1637 SWALL:AAN43220 (EMBL:AE015185) (502 aa) fasta scores: E(): 3.5e-65, 38.67% id in 512 aa.
  
     0.591
fliT
Flagellar protein; Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
  
     0.586
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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