STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa)    
Predicted Functional Partners:
trpC
N-(5'-phosphoribosyl)anthranilate isomerase; Similar to Escherichia coli tryptophan biosynthesis protein TrpC [includes: indole-3-glycerol phosphate synthase trpc or b1262 SWALL:TRPC_ECOLI (SWALL:P00909) (452 aa) fasta scores: E(): 1.6e-121, 69.93% id in 449 aa.
 
 
 0.999
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 0.999
trpG
Similar to Serratia marcescens anthranilate synthase component II TrpG SWALL:TRPG_SERMA (SWALL:P00900) (192 aa) fasta scores: E(): 6.3e-60, 85.34% id in 191 aa, and to Yersinia pestis anthranilate synthase component II TrpG or ypo2207 or y2050.1 SWALL:Q8ZEG6 (EMBL:AJ414151) (192 aa) fasta scores: E(): 5.4e-62, 84.89% id in 192 aa.
 
  
 0.996
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
  
 0.984
trpE
Similar to Escherichia coli anthranilate synthase component I TrpE or b1264 SWALL:TRPE_ECOLI (SWALL:P00895) (520 aa) fasta scores: E(): 2.8e-154, 77.5% id in 520 aa.
 
  
 0.974
ehpC
Putative phenazine antibiotic biosynthesis protein; Similar to Pseudomonas aeruginosa PhzE and pa4214 SWALL:O33410 (EMBL:AF005404) (627 aa) fasta scores: E(): 1.2e-105, 45.65% id in 622 aa, and to Pantoea agglomerans EhpC SWALL:AAN40892 (EMBL:AF451953) (634 aa) fasta scores: E(): 6.8e-55, 37.82% id in 624 aa.
 
  
 0.973
ECA4066
Para-aminobenzoate synthase, glutamine amidotransferase component II.
 
  
 0.925
glyA2
Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 
 
 0.923
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 
 
 0.921
tdcB
Putative threonine dehydratase catabolic; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri threonine dehydratase catabolic TdcB or b3117 or c3875 or z4469 or ecs3997 or sf3157 SWALL:THD2_ECOLI (SWALL:P05792) (329 aa) fasta scores: E(): 9.6e-33, 38.14% id in 312 aa, and to Thermotoga maritima threonine dehydratase catabolic tm0356 SWALL:Q9WYJ1 (EMBL:AE001716) (401 aa) fasta scores: E(): 6.1e-41, 41.32% id in 317 aa.
  
 
 0.918
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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