Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ispZIntracellular septation protein; Involved in cell division; probably involved in intracellular septation; Belongs to the YciB family. (188 aa)    
Predicted Functional Partners:
ECA2314
Putative acyl-CoA thioester hydrolase; Similar to Escherichia coli, Escherichia coli O6, and Shigella flexneri putative acyl-CoA thioester hydrolase ycia or b1253 or c1719 or sf1256 SWALL:YCIA_ECOLI (SWALL:P04379) (132 aa) fasta scores: E(): 1.2e-41, 80% id in 130 aa, and to Yersinia pestis putative acyl-CoA thioester hydrolase ypo2195 or y2039 SWALL:Q8ZEH6 (EMBL:AJ414151) (149 aa) fasta scores: E(): 1.5e-44, 86.15% id in 130 aa.
       0.758
ECA2305
Similar to Yersinia pestis putative membrane protein ypo2199 or y2042 SWALL:Q8ZEH4 (EMBL:AJ414151) (256 aa) fasta scores: E(): 8.8e-50, 55.42% id in 249 aa, and to Salmonella typhimurium putative inner membrane protein ycic or stm1734 SWALL:Q8ZP49 (EMBL:AE008777) (247 aa) fasta scores: E(): 9.6e-49, 55.82% id in 249 aa.
  
    0.652
hflB
Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
      
 0.531
secY
Preprotein translocase subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
  
   
 0.518
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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