Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ECA2316Conserved hypothetical protein; Similar to Escherichia coli, Escherichia coli O6, and Shigella flexneri protein ycii or b1251 or c1716 or sf1254 SWALL:YCII_ECOLI (SWALL:P31070) (98 aa) fasta scores: E(): 7.2e-27, 75.51% id in 98 aa, and to Salmonella typhimurium, and Salmonella typhi putative cytoplasmic protein ycii or stm1738 or sty1313 SWALL:Q8XH04 (EMBL:AE008777) (98 aa) fasta scores: E(): 4.4e-26, 72.44% id in 98 aa. (98 aa)    
Predicted Functional Partners:
ECA2317
Similar to Escherichia coli methyl-accepting chemotaxis protein I Tsr or CheD or b4355 SWALL:MCP1_ECOLI (SWALL:P02942) (551 aa) fasta scores: E(): 2.1e-47, 31.81% id in 528 aa, and to Yersinia pestis putative methyl-accepting chemotaxis protein y3190 SWALL:AAM86740 (EMBL:AE013920) (566 aa) fasta scores: E(): 8e-81, 47.86% id in 516 aa.
       0.768
lptA
Putative exported protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
  
     0.612
tonB
TonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.
 
  
 0.548
tatA
Sec-independent protein translocase; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
  
    0.547
tatE
Sec-independent protein translocase protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA; Belongs to the TatA/E family. TatE subfamily.
  
    0.508
cls
Cardiolipin synthetase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
      0.498
mreD
Rod shape-determining protein; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family.
  
     0.463
hisI
Similar to Escherichia coli histidine biosynthesis bifunctional protein HisIE [includes: phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphatase HisI or hisie or b2026 SWALL:HIS2_ECOLI (SWALL:P06989) (203 aa) fasta scores: E(): 2e-64, 80.09% id in 201 aa; In the N-terminal section; belongs to the PRA-CH family.
  
  
 0.459
hflD
Similar to Escherichia coli hypothetical protein ycfc or b1132 SWALL:YCFC_ECOLI (SWALL:P25746) (213 aa) fasta scores: E(): 2.3e-55, 71.98% id in 207 aa, and to Salmonella typhi hypothetical protein Sty1273 SWALL:Q8Z7H0 (EMBL:AL627269) (215 aa) fasta scores: E(): 7.5e-53, 68.59% id in 207 aa.
  
    0.458
diaA
Putative phosphoheptose isomerase; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily.
   
    0.438
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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