STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ECA2336Similar to Yersinia pestis putative exported protein ypo2166 or y2155 SWALL:Q8ZEJ9 (EMBL:AJ414151) (96 aa) fasta scores: E(): 5.7e-17, 48.91% id in 92 aa, and to Salmonella typhi putative exported protein sty1814 SWALL:Q8Z6F7 (EMBL:AL627271) (91 aa) fasta scores: E(): 2e-14, 50% id in 86 aa. (96 aa)    
Predicted Functional Partners:
topB-2
DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...]
       0.786
ECA2338
Similar to Yersinia pestis putative nitroreductase ypo2163 or y2159 SWALL:Q8ZEK2 (EMBL:AJ414151) (183 aa) fasta scores: E(): 1.3e-57, 73.22% id in 183 aa, and to Salmonella typhimurium, and Salmonella typhi putative oxidoreductase ydja or stm1296 or sty1818 SWALL:Q8XGY1 (EMBL:AE008756) (183 aa) fasta scores: E(): 4.3e-52, 69.39% id in 183 aa.
       0.592
ycgR
Conserved hypothetical protein; Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility.
   
  
 0.446
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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