STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ECA2338Similar to Yersinia pestis putative nitroreductase ypo2163 or y2159 SWALL:Q8ZEK2 (EMBL:AJ414151) (183 aa) fasta scores: E(): 1.3e-57, 73.22% id in 183 aa, and to Salmonella typhimurium, and Salmonella typhi putative oxidoreductase ydja or stm1296 or sty1818 SWALL:Q8XGY1 (EMBL:AE008756) (183 aa) fasta scores: E(): 4.3e-52, 69.39% id in 183 aa. (183 aa)    
Predicted Functional Partners:
topB-2
DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...]
     
 0.643
ECA2336
Similar to Yersinia pestis putative exported protein ypo2166 or y2155 SWALL:Q8ZEJ9 (EMBL:AJ414151) (96 aa) fasta scores: E(): 5.7e-17, 48.91% id in 92 aa, and to Salmonella typhi putative exported protein sty1814 SWALL:Q8Z6F7 (EMBL:AL627271) (91 aa) fasta scores: E(): 2e-14, 50% id in 86 aa.
       0.626
ECA2595
Similar to Yersinia pestis hypothetical protein Ypo1385 SWALL:Q8ZGB8 (EMBL:AJ414148) (588 aa) fasta scores: E(): 5.2e-206, 84.24% id in 584 aa, and to Escherichia coli hypothetical protein ycao or b0905 SWALL:YCAO_ECOLI (SWALL:P75838) (586 aa) fasta scores: E(): 1.9e-200, 81.84% id in 584 aa.
  
  
 0.614
gltB
Similar to Escherichia coli glutamate synthase [NADPH] large chain precursor GltB or AspB SWALL:GLTB_ECOLI (SWALL:P09831) (1517 aa) fasta scores: E(): 0, 86.75% id in 1495 aa, and to Yersinia pestis glutamate synthase, large subunit GltB SWALL:AAM83722 (EMBL:AE013613) (1535 aa) fasta scores: E(): 0, 90.25% id in 1498 aa.
     
 0.582
ECA3324
Similar to Salmonella typhi ABC transporter integral membrane protein sty0195 SWALL:Q8Z9D6 (EMBL:AL627265) (256 aa) fasta scores: E(): 1.6e-82, 83.59% id in 256 aa, and to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri hypothetical protein yadh or b0128 or c0157 or z0139 or ecs0132 or sf0125 SWALL:YADH_ECOLI (SWALL:P36880) (256 aa) fasta scores: E(): 1.3e-81, 82.42% id in 256 aa.
  
  
 0.582
birA
Bira bifunctional protein [includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
  
    0.579
ECA0422
Putative membrane protein; Similar to Vibrio vulnificus ABC-type multidrug transport system, permease component vv12691 SWALL:AAO11038 (EMBL:AE016806) (381 aa) fasta scores: E(): 1.2e-62, 45.26% id in 391 aa.
  
  
 0.536
ECA0423
Putative membrane protein; Similar to Vibrio cholerae hypothetical protein Vc1608 vc1608 SWALL:Q9KRM8 (EMBL:AE004238) (387 aa) fasta scores: E(): 3.2e-46, 38.08% id in 365 aa.
  
  
 0.536
tadA
Putative cytidine and deoxycytidylate deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
  
  
 0.523
sppA
Protease IV; Similar to Escherichia coli protease IV SppA or b1766 SWALL:SPPA_ECOLI (SWALL:P08395) (618 aa) fasta scores: E(): 2e-156, 66.34% id in 618 aa.
     
 0.521
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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