Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sdaAL-serine dehydratase 1; Similar to Escherichia coli L-serine dehydratase 1 SdaA or b1814 SWALL:SDHL_ECOLI (SWALL:P16095) (454 aa) fasta scores: E(): 5.1e-154, 83.92% id in 454 aa. Also similar to ECA3159 (SdaB) (75.165% id. in 455 aa overlap); Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.972
glyA2
Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.972
ilvA
Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.952
thrA
Similar to Escherichia coli bifunctional aspartokinase/homoserine dehydrogenase I [includes: aspartokinase I; homoserine dehydrogenase I] thra or thra1 or thra2 or b0002 SWALL:AK1H_ECOLI (SWALL:P00561) (820 aa) fasta scores: E(): 0, 82.41% id in 819 aa; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.951
metL
Similar to Escherichia coli bifunctional aspartokinase/homoserine dehydrogenase II MetL or MetM or b3940 SWALL:AK2H_ECOLI (SWALL:P00562) (809 aa) fasta scores: E(): 0, 83.12% id in 800 aa; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.951
cysE
Serine acetyltransferase; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri serine acetyltransferase CysEor b3607 or c4429 or z5034 or ecs4485 or sf3646 SWALL:CYSE_ECOLI (SWALL:P05796) (273 aa) fasta scores: E(): 5.1e-90, 86.08% id in 273 aa, and to Yersinia pestis serine acetyltransferase CysE SWALL:Q8ZJM4 (EMBL:AJ414141) (273 aa) fasta scores: E(): 1.5e-92, 89.37% id in 273 aa.
     
 0.950
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.950
serB
Phosphoserine phosphatase; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri phosphoserine phosphatase SerB or b4388 or z5989 or ecs5346 or sf4420 SWALL:SERB_ECOLI (SWALL:P06862) (322 aa) fasta scores: E(): 5.7e-81, 71.87% id in 320 aa.
   
 
 0.949
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
   
 
 0.949
metA
Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family.
     
 0.946
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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