Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CspCCold shock protein; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, Salmonella typhimurium, and Salmonella typhi cold shock-like protein CspC SWALL:CSPC_ECOLI (SWALL:P36996) (68 aa) fasta scores: E(): 3.2e-25, 97.05% id in 68 aa, and to Yersinia pestis cold shock protein ypo1746 SWALL:Q8ZFG3 (EMBL:AJ414150) (69 aa) fasta scores: E(): 5.2e-26, 98.55% id in 69 aa. (69 aa)    
Predicted Functional Partners:
groS
10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
  
  
 0.592
rseA
sigma-E factor negative regulator; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases [...]
      
 0.572
rrmA
Similar to Escherichia coli ribosomal RNA large subunit methyltransferase A RrmA or b1822 SWALL:RRMA_ECOLI (SWALL:P36999) (269 aa) fasta scores: E(): 2.3e-62, 60.37% id in 270 aa.
     
 0.569
grpE
Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...]
     
 0.568
groL
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
   
 
 0.562
rpsL
30S ribosomal subunit protein S12; With S4 and S5 plays an important role in translational accuracy.
   
 
 0.496
rpsS
30S ribosomal subunit protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
   
 
 0.490
rplW
50S ribosomal subunit protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family.
   
   0.475
ECA1051
Similar to Yersinia pestis hypothetical protein Ypo1065 SWALL:Q8ZH46 (EMBL:AJ414146) (182 aa) fasta scores: E(): 2.4e-56, 75.28% id in 178 aa, and to Escherichia coli O6 hypothetical protein yaeq or c0229 SWALL:AAN78721 (EMBL:AE016755) (181 aa) fasta scores: E(): 6e-48, 62.22% id in 180 aa.
  
    0.469
rpsQ
30S ribosomal subunit protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
   
 
 0.466
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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