| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ECA1220 | dnaJ | ECA1220 | ECA3881 | Similar to Yersinia pestis putative thioredoxin ypo3082 or y1097 SWALL:Q8ZCB1 (EMBL:AJ414155) (289 aa) fasta scores: E(): 1e-69, 71.93% id in 285 aa, and to Escherichia coli hypothetical protein ybbn or b0492 SWALL:YBBN_ECOLI (SWALL:P77395) (284 aa) fasta scores: E(): 3.8e-68, 70.96% id in 279 aa. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.681 |
| ECA1220 | fxsA | ECA1220 | ECA0623 | Similar to Yersinia pestis putative thioredoxin ypo3082 or y1097 SWALL:Q8ZCB1 (EMBL:AJ414155) (289 aa) fasta scores: E(): 1e-69, 71.93% id in 285 aa, and to Escherichia coli hypothetical protein ybbn or b0492 SWALL:YBBN_ECOLI (SWALL:P77395) (284 aa) fasta scores: E(): 3.8e-68, 70.96% id in 279 aa. | Suppressor of F plamsid exlusion of phage T7; Similar to Escherichia coli FxsA protein FxsA or b4140 SWALL:FXSA_ECOLI (SWALL:P37147) (158 aa) fasta scores: E(): 1.3e-38, 68.35% id in 158 aa. | 0.771 |
| ECA1220 | grpE | ECA1220 | ECA0842 | Similar to Yersinia pestis putative thioredoxin ypo3082 or y1097 SWALL:Q8ZCB1 (EMBL:AJ414155) (289 aa) fasta scores: E(): 1e-69, 71.93% id in 285 aa, and to Escherichia coli hypothetical protein ybbn or b0492 SWALL:YBBN_ECOLI (SWALL:P77395) (284 aa) fasta scores: E(): 3.8e-68, 70.96% id in 279 aa. | Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...] | 0.914 |
| ECA1220 | hslU | ECA1220 | ECA4262 | Similar to Yersinia pestis putative thioredoxin ypo3082 or y1097 SWALL:Q8ZCB1 (EMBL:AJ414155) (289 aa) fasta scores: E(): 1e-69, 71.93% id in 285 aa, and to Escherichia coli hypothetical protein ybbn or b0492 SWALL:YBBN_ECOLI (SWALL:P77395) (284 aa) fasta scores: E(): 3.8e-68, 70.96% id in 279 aa. | ATP-dependent Hsl protease ATP-binding subunit (heat shock protein); ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.911 |
| ECA1220 | htpX | ECA1220 | ECA2427 | Similar to Yersinia pestis putative thioredoxin ypo3082 or y1097 SWALL:Q8ZCB1 (EMBL:AJ414155) (289 aa) fasta scores: E(): 1e-69, 71.93% id in 285 aa, and to Escherichia coli hypothetical protein ybbn or b0492 SWALL:YBBN_ECOLI (SWALL:P77395) (284 aa) fasta scores: E(): 3.8e-68, 70.96% id in 279 aa. | Heat shock protein; Similar to Escherichia coli probable protease HtpX or b1829 SWALL:HTPX_ECOLI (SWALL:P23894) (293 aa) fasta scores: E(): 1.5e-100, 89.76% id in 293 aa; Belongs to the peptidase M48B family. | 0.570 |
| ECA1747 | htpX | ECA1747 | ECA2427 | Conserved hypothetical protein; Similar to Escherichia coli O157:H7 orf, hypothetical protein yebe or z2897 or ecs2556 SWALL:Q8XCK2 (EMBL:AE005407) (219 aa) fasta scores: E(): 5e-42, 57% id in 214 aa, and to Shigella flexneri orf, conserved hypothetical protein yebe or sf1857 SWALL:AAN43415 (EMBL:AE015204) (219 aa) fasta scores: E(): 3.1e-41, 56.07% id in 214 aa. | Heat shock protein; Similar to Escherichia coli probable protease HtpX or b1829 SWALL:HTPX_ECOLI (SWALL:P23894) (293 aa) fasta scores: E(): 1.5e-100, 89.76% id in 293 aa; Belongs to the peptidase M48B family. | 0.610 |
| ECA1763 | hflB | ECA1763 | ECA0698 | Similar to Salmonella typhi putative membrane protein sty1112 SWALL:Q8Z7R5 (EMBL:AL627269) (219 aa) fasta scores: E(): 2.3e-60, 77.16% id in 219 aa, and to Escherichia coli O157:H7 putative carrier/transport protein ycca or z1322 or ecs1054 SWALL:Q8XD81 (EMBL:AE005287) (219 aa) fasta scores: E(): 4e-60, 76.25% id in 219 aa; Belongs to the BI1 family. | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.405 |
| ECA1763 | htpX | ECA1763 | ECA2427 | Similar to Salmonella typhi putative membrane protein sty1112 SWALL:Q8Z7R5 (EMBL:AL627269) (219 aa) fasta scores: E(): 2.3e-60, 77.16% id in 219 aa, and to Escherichia coli O157:H7 putative carrier/transport protein ycca or z1322 or ecs1054 SWALL:Q8XD81 (EMBL:AE005287) (219 aa) fasta scores: E(): 4e-60, 76.25% id in 219 aa; Belongs to the BI1 family. | Heat shock protein; Similar to Escherichia coli probable protease HtpX or b1829 SWALL:HTPX_ECOLI (SWALL:P23894) (293 aa) fasta scores: E(): 1.5e-100, 89.76% id in 293 aa; Belongs to the peptidase M48B family. | 0.679 |
| clpP | dnaJ | ECA1148 | ECA3881 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.537 |
| clpP | grpE | ECA1148 | ECA0842 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...] | 0.717 |
| clpP | hflB | ECA1148 | ECA0698 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.641 |
| clpP | hslU | ECA1148 | ECA4262 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Hsl protease ATP-binding subunit (heat shock protein); ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.597 |
| clpP | htpX | ECA1148 | ECA2427 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Heat shock protein; Similar to Escherichia coli probable protease HtpX or b1829 SWALL:HTPX_ECOLI (SWALL:P23894) (293 aa) fasta scores: E(): 1.5e-100, 89.76% id in 293 aa; Belongs to the peptidase M48B family. | 0.571 |
| clpP | rpoH | ECA1148 | ECA4343 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | RNA polymerase sigma-32 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. | 0.606 |
| dnaJ | ECA1220 | ECA3881 | ECA1220 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Similar to Yersinia pestis putative thioredoxin ypo3082 or y1097 SWALL:Q8ZCB1 (EMBL:AJ414155) (289 aa) fasta scores: E(): 1e-69, 71.93% id in 285 aa, and to Escherichia coli hypothetical protein ybbn or b0492 SWALL:YBBN_ECOLI (SWALL:P77395) (284 aa) fasta scores: E(): 3.8e-68, 70.96% id in 279 aa. | 0.681 |
| dnaJ | clpP | ECA3881 | ECA1148 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.537 |
| dnaJ | grpE | ECA3881 | ECA0842 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...] | 0.996 |
| dnaJ | hflB | ECA3881 | ECA0698 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.811 |
| dnaJ | hslU | ECA3881 | ECA4262 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | ATP-dependent Hsl protease ATP-binding subunit (heat shock protein); ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.969 |
| dnaJ | htpX | ECA3881 | ECA2427 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Heat shock protein; Similar to Escherichia coli probable protease HtpX or b1829 SWALL:HTPX_ECOLI (SWALL:P23894) (293 aa) fasta scores: E(): 1.5e-100, 89.76% id in 293 aa; Belongs to the peptidase M48B family. | 0.647 |
