STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nudBDATP pyrophosphohydrolase; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri DATP pyrophosphohydrolase NudB or NtpA or b1865 or z2917 or ecs2575 or sf1875 SWALL:NUDB_ECOLI (SWALL:P24236) (150 aa) fasta scores: E(): 7e-46, 76.02% id in 146 aa. (147 aa)    
Predicted Functional Partners:
ECA3553
Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri putative 6-pyruvoyl tetrahydrobiopterin synthase YgcM or b2765 or z4075 or ecs3620 or sf2781 SWALL:PTPS_ECOLI (SWALL:Q46903) (121 aa) fasta scores: E(): 8.1e-44, 86.66% id in 120 aa.
 
  
  0.916
folE
GTP cyclohydrolase I; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri GTP cyclohydrolase I FolE or b2153 or c2688 or z3409 or ecs3045 or sf2238 SWALL:GCH1_ECOLI (SWALL:P27511) (221 aa) fasta scores: E(): 9.1e-71, 88.18% id in 220 aa.
    
 0.911
aspS
aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
  
   0.905
ECA4130
Alkaline phosphatase; Similar to Schizophyllum commune alkaline phosphatase Pho1 SWALL:Q9UR10 (EMBL:AF209194) (604 aa) fasta scores: E(): 5.3e-20, 32.91% id in 477 aa, and to Schizosaccharomyces pombe alkaline phosphatase spbc14f5.13C SWALL:PPB_SCHPO (SWALL:O60109) (532 aa) fasta scores: E(): 8.8e-15, 26.68% id in 491 aa.
     
 0.904
folX
D-erythro-7,8-dihydroneopterin triphosphate epimerase; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri D-erythro-7,8-dihydroneopterin triphosphate epimerase FolX or b2303 or c2846 or z3565 or ecs3187 or sf2379 SWALL:FOLX_ECOLI (SWALL:P80449) (119 aa) fasta scores: E(): 1.1e-32, 77.39% id in 115 aa.
    
  0.901
ECA2494
Similar to Yersinia pestis hypothetical protein Ypo2055 SWALL:Q8ZEU8 (EMBL:AJ414151) (247 aa) fasta scores: E(): 2.7e-83, 91.09% id in 247 aa, and to Escherichia coli protein yebc or b1864 SWALL:YEBC_ECOLI (SWALL:P24237) (246 aa) fasta scores: E(): 4.9e-81, 87.44% id in 247 aa.
  
  
 0.881
nnrE
Putative carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of [...]
  
 0.731
ruvC
Crossover junction endodeoxyribonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
  
  
 0.637
birA
Bira bifunctional protein [includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
   
    0.559
imp
Organic solvent tolerance protein precursor; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
  
    0.485
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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