STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ycgRConserved hypothetical protein; Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility. (251 aa)    
Predicted Functional Partners:
flgM
Similar to Escherichia coli, and Shigella flexneri negative regulator of flagellin synthesis FlgM or b1071 or sf1077 SWALL:FLGM_ECOLI (SWALL:P43532) (97 aa) fasta scores: E(): 4.5e-14, 59.18% id in 98 aa.
 
  
 0.919
fliA
RNA polymerase sigma factor for flagellar operon; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily.
 
  
 0.897
ECA3271
Similar to Yersinia pestis hypothetical protein Ypo3988 SWALL:Q8ZA32 (EMBL:AJ414160) (276 aa) fasta scores: E(): 1.6e-49, 51.48% id in 235 aa, and to Escherichia coli O157:H7 orf, hypothetical protein yhjh or z4939 or ecs4405 SWALL:Q8X5M5 (EMBL:AE005578) (255 aa) fasta scores: E(): 5.4e-46, 50.63% id in 237 aa.
 
 
 0.886
fliS
Flagellar protein; Similar to Salmonella typhimurium flagellar protein FliS or stm1961 SWALL:FLIS_SALTY (SWALL:P26609) (135 aa) fasta scores: E(): 1.4e-30, 69.85% id in 136 aa, and to Erwinia chrysanthemi FliS protein FliS SWALL:Q8RST3 (EMBL:AJ430202) (136 aa) fasta scores: E(): 4.4e-33, 73.52% id in 136 aa.
 
  
 0.874
fliD
Flagellar hook-associated protein 2; Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
  
  
 0.820
cheR
Chemotaxis protein methyltransferase; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
  
  
 0.797
flhD
Flagellar transcriptional activator; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family.
  
  
 0.785
flhC
Flagellar transcriptional activator; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family.
   
  
 0.771
cheZ
Chemotaxis protein; Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).
 
  
 0.769
ECA1568
Putative chemotaxis signal transduction protein; Similar to Vibrio fischeri CheV SWALL:AAL86625 (EMBL:AY079167) (306 aa) fasta scores: E(): 1.6e-26, 34.36% id in 323 aa, and to Salmonella typhimurium putative chemotaxis signal transduction protein stm2314 SWALL:Q8ZNE6 (EMBL:AE008803) (333 aa) fasta scores: E(): 8.2e-81, 70.44% id in 318 aa.
 
  
 0.766
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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