node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ECA2250 | hisA | ECA2250 | ECA2587 | Putative aminotransferase; Similar to Xanthomonas campestris histidinol-phosphate aminotransferase hisc or xcc3275 SWALL:Q8P5R1 (EMBL:AE012444) (399 aa) fasta scores: E(): 2.9e-27, 31.33% id in 367 aa, and to Pseudomonas fluorescens putative aminotransferase qbsB SWALL:AAL65284 (EMBL:AY072690) (363 aa) fasta scores: E(): 1.1e-26, 32.2% id in 354 aa. | Similar to Escherichia coli 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA or z3186 or ecs2825 SWALL:HIS4_ECO57 (SWALL:Q9S5G4) (245 aa) fasta scores: E(): 4.1e-69, 75.81% id in 244 aa. | 0.834 |
ECA2250 | hisB | ECA2250 | ECA2585 | Putative aminotransferase; Similar to Xanthomonas campestris histidinol-phosphate aminotransferase hisc or xcc3275 SWALL:Q8P5R1 (EMBL:AE012444) (399 aa) fasta scores: E(): 2.9e-27, 31.33% id in 367 aa, and to Pseudomonas fluorescens putative aminotransferase qbsB SWALL:AAL65284 (EMBL:AY072690) (363 aa) fasta scores: E(): 1.1e-26, 32.2% id in 354 aa. | Similar to Escherichia coli histidine biosynthesis bifunctional protein HisB [includes: histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase] HisB or b2022 SWALL:HIS7_ECOLI (SWALL:P06987) (355 aa) fasta scores: E(): 1.6e-119, 82.81% id in 355 aa. | 0.997 |
ECA2250 | hisC | ECA2250 | ECA2584 | Putative aminotransferase; Similar to Xanthomonas campestris histidinol-phosphate aminotransferase hisc or xcc3275 SWALL:Q8P5R1 (EMBL:AE012444) (399 aa) fasta scores: E(): 2.9e-27, 31.33% id in 367 aa, and to Pseudomonas fluorescens putative aminotransferase qbsB SWALL:AAL65284 (EMBL:AY072690) (363 aa) fasta scores: E(): 1.1e-26, 32.2% id in 354 aa. | Similar to Escherichia coli histidinol-phosphate aminotransferase HisC or b2021 SWALL:HIS8_ECOLI (SWALL:P06986) (356 aa) fasta scores: E(): 1e-103, 75.07% id in 349 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.919 |
ECA2250 | hisD | ECA2250 | ECA2583 | Putative aminotransferase; Similar to Xanthomonas campestris histidinol-phosphate aminotransferase hisc or xcc3275 SWALL:Q8P5R1 (EMBL:AE012444) (399 aa) fasta scores: E(): 2.9e-27, 31.33% id in 367 aa, and to Pseudomonas fluorescens putative aminotransferase qbsB SWALL:AAL65284 (EMBL:AY072690) (363 aa) fasta scores: E(): 1.1e-26, 32.2% id in 354 aa. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.901 |
ECA2250 | hisF | ECA2250 | ECA2588 | Putative aminotransferase; Similar to Xanthomonas campestris histidinol-phosphate aminotransferase hisc or xcc3275 SWALL:Q8P5R1 (EMBL:AE012444) (399 aa) fasta scores: E(): 2.9e-27, 31.33% id in 367 aa, and to Pseudomonas fluorescens putative aminotransferase qbsB SWALL:AAL65284 (EMBL:AY072690) (363 aa) fasta scores: E(): 1.1e-26, 32.2% id in 354 aa. | Imidazole glycerol phosphate synthase subunit hisf; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.863 |
ECA2250 | hisG | ECA2250 | ECA2582 | Putative aminotransferase; Similar to Xanthomonas campestris histidinol-phosphate aminotransferase hisc or xcc3275 SWALL:Q8P5R1 (EMBL:AE012444) (399 aa) fasta scores: E(): 2.9e-27, 31.33% id in 367 aa, and to Pseudomonas fluorescens putative aminotransferase qbsB SWALL:AAL65284 (EMBL:AY072690) (363 aa) fasta scores: E(): 1.1e-26, 32.2% id in 354 aa. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.815 |
ECA2250 | hisH | ECA2250 | ECA2586 | Putative aminotransferase; Similar to Xanthomonas campestris histidinol-phosphate aminotransferase hisc or xcc3275 SWALL:Q8P5R1 (EMBL:AE012444) (399 aa) fasta scores: E(): 2.9e-27, 31.33% id in 367 aa, and to Pseudomonas fluorescens putative aminotransferase qbsB SWALL:AAL65284 (EMBL:AY072690) (363 aa) fasta scores: E(): 1.1e-26, 32.2% id in 354 aa. | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.864 |
ECA2250 | hisI | ECA2250 | ECA2589 | Putative aminotransferase; Similar to Xanthomonas campestris histidinol-phosphate aminotransferase hisc or xcc3275 SWALL:Q8P5R1 (EMBL:AE012444) (399 aa) fasta scores: E(): 2.9e-27, 31.33% id in 367 aa, and to Pseudomonas fluorescens putative aminotransferase qbsB SWALL:AAL65284 (EMBL:AY072690) (363 aa) fasta scores: E(): 1.1e-26, 32.2% id in 354 aa. | Similar to Escherichia coli histidine biosynthesis bifunctional protein HisIE [includes: phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphatase HisI or hisie or b2026 SWALL:HIS2_ECOLI (SWALL:P06989) (203 aa) fasta scores: E(): 2e-64, 80.09% id in 201 aa; In the N-terminal section; belongs to the PRA-CH family. | 0.973 |
ECA2250 | metL | ECA2250 | ECA4251 | Putative aminotransferase; Similar to Xanthomonas campestris histidinol-phosphate aminotransferase hisc or xcc3275 SWALL:Q8P5R1 (EMBL:AE012444) (399 aa) fasta scores: E(): 2.9e-27, 31.33% id in 367 aa, and to Pseudomonas fluorescens putative aminotransferase qbsB SWALL:AAL65284 (EMBL:AY072690) (363 aa) fasta scores: E(): 1.1e-26, 32.2% id in 354 aa. | Similar to Escherichia coli bifunctional aspartokinase/homoserine dehydrogenase II MetL or MetM or b3940 SWALL:AK2H_ECOLI (SWALL:P00562) (809 aa) fasta scores: E(): 0, 83.12% id in 800 aa; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.843 |
ECA2250 | thrA | ECA2250 | ECA3891 | Putative aminotransferase; Similar to Xanthomonas campestris histidinol-phosphate aminotransferase hisc or xcc3275 SWALL:Q8P5R1 (EMBL:AE012444) (399 aa) fasta scores: E(): 2.9e-27, 31.33% id in 367 aa, and to Pseudomonas fluorescens putative aminotransferase qbsB SWALL:AAL65284 (EMBL:AY072690) (363 aa) fasta scores: E(): 1.1e-26, 32.2% id in 354 aa. | Similar to Escherichia coli bifunctional aspartokinase/homoserine dehydrogenase I [includes: aspartokinase I; homoserine dehydrogenase I] thra or thra1 or thra2 or b0002 SWALL:AK1H_ECOLI (SWALL:P00561) (820 aa) fasta scores: E(): 0, 82.41% id in 819 aa; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.863 |
hisA | ECA2250 | ECA2587 | ECA2250 | Similar to Escherichia coli 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA or z3186 or ecs2825 SWALL:HIS4_ECO57 (SWALL:Q9S5G4) (245 aa) fasta scores: E(): 4.1e-69, 75.81% id in 244 aa. | Putative aminotransferase; Similar to Xanthomonas campestris histidinol-phosphate aminotransferase hisc or xcc3275 SWALL:Q8P5R1 (EMBL:AE012444) (399 aa) fasta scores: E(): 2.9e-27, 31.33% id in 367 aa, and to Pseudomonas fluorescens putative aminotransferase qbsB SWALL:AAL65284 (EMBL:AY072690) (363 aa) fasta scores: E(): 1.1e-26, 32.2% id in 354 aa. | 0.834 |
hisA | hisB | ECA2587 | ECA2585 | Similar to Escherichia coli 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA or z3186 or ecs2825 SWALL:HIS4_ECO57 (SWALL:Q9S5G4) (245 aa) fasta scores: E(): 4.1e-69, 75.81% id in 244 aa. | Similar to Escherichia coli histidine biosynthesis bifunctional protein HisB [includes: histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase] HisB or b2022 SWALL:HIS7_ECOLI (SWALL:P06987) (355 aa) fasta scores: E(): 1.6e-119, 82.81% id in 355 aa. | 0.997 |
hisA | hisC | ECA2587 | ECA2584 | Similar to Escherichia coli 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA or z3186 or ecs2825 SWALL:HIS4_ECO57 (SWALL:Q9S5G4) (245 aa) fasta scores: E(): 4.1e-69, 75.81% id in 244 aa. | Similar to Escherichia coli histidinol-phosphate aminotransferase HisC or b2021 SWALL:HIS8_ECOLI (SWALL:P06986) (356 aa) fasta scores: E(): 1e-103, 75.07% id in 349 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.981 |
hisA | hisD | ECA2587 | ECA2583 | Similar to Escherichia coli 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA or z3186 or ecs2825 SWALL:HIS4_ECO57 (SWALL:Q9S5G4) (245 aa) fasta scores: E(): 4.1e-69, 75.81% id in 244 aa. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.995 |
hisA | hisF | ECA2587 | ECA2588 | Similar to Escherichia coli 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA or z3186 or ecs2825 SWALL:HIS4_ECO57 (SWALL:Q9S5G4) (245 aa) fasta scores: E(): 4.1e-69, 75.81% id in 244 aa. | Imidazole glycerol phosphate synthase subunit hisf; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | ECA2587 | ECA2582 | Similar to Escherichia coli 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA or z3186 or ecs2825 SWALL:HIS4_ECO57 (SWALL:Q9S5G4) (245 aa) fasta scores: E(): 4.1e-69, 75.81% id in 244 aa. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.995 |
hisA | hisH | ECA2587 | ECA2586 | Similar to Escherichia coli 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA or z3186 or ecs2825 SWALL:HIS4_ECO57 (SWALL:Q9S5G4) (245 aa) fasta scores: E(): 4.1e-69, 75.81% id in 244 aa. | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | ECA2587 | ECA2589 | Similar to Escherichia coli 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA or z3186 or ecs2825 SWALL:HIS4_ECO57 (SWALL:Q9S5G4) (245 aa) fasta scores: E(): 4.1e-69, 75.81% id in 244 aa. | Similar to Escherichia coli histidine biosynthesis bifunctional protein HisIE [includes: phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphatase HisI or hisie or b2026 SWALL:HIS2_ECOLI (SWALL:P06989) (203 aa) fasta scores: E(): 2e-64, 80.09% id in 201 aa; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | metL | ECA2587 | ECA4251 | Similar to Escherichia coli 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA or z3186 or ecs2825 SWALL:HIS4_ECO57 (SWALL:Q9S5G4) (245 aa) fasta scores: E(): 4.1e-69, 75.81% id in 244 aa. | Similar to Escherichia coli bifunctional aspartokinase/homoserine dehydrogenase II MetL or MetM or b3940 SWALL:AK2H_ECOLI (SWALL:P00562) (809 aa) fasta scores: E(): 0, 83.12% id in 800 aa; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.603 |
hisA | thrA | ECA2587 | ECA3891 | Similar to Escherichia coli 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA or z3186 or ecs2825 SWALL:HIS4_ECO57 (SWALL:Q9S5G4) (245 aa) fasta scores: E(): 4.1e-69, 75.81% id in 244 aa. | Similar to Escherichia coli bifunctional aspartokinase/homoserine dehydrogenase I [includes: aspartokinase I; homoserine dehydrogenase I] thra or thra1 or thra2 or b0002 SWALL:AK1H_ECOLI (SWALL:P00561) (820 aa) fasta scores: E(): 0, 82.41% id in 819 aa; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.603 |