STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisBSimilar to Escherichia coli histidine biosynthesis bifunctional protein HisB [includes: histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase] HisB or b2022 SWALL:HIS7_ECOLI (SWALL:P06987) (355 aa) fasta scores: E(): 1.6e-119, 82.81% id in 355 aa. (355 aa)    
Predicted Functional Partners:
ECA2250
Putative aminotransferase; Similar to Xanthomonas campestris histidinol-phosphate aminotransferase hisc or xcc3275 SWALL:Q8P5R1 (EMBL:AE012444) (399 aa) fasta scores: E(): 2.9e-27, 31.33% id in 367 aa, and to Pseudomonas fluorescens putative aminotransferase qbsB SWALL:AAL65284 (EMBL:AY072690) (363 aa) fasta scores: E(): 1.1e-26, 32.2% id in 354 aa.
 
 0.999
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
 
  
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
 0.999
hisC
Similar to Escherichia coli histidinol-phosphate aminotransferase HisC or b2021 SWALL:HIS8_ECOLI (SWALL:P06986) (356 aa) fasta scores: E(): 1e-103, 75.07% id in 349 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
 0.999
hisH
Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 
 0.999
hisA
Similar to Escherichia coli 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA or z3186 or ecs2825 SWALL:HIS4_ECO57 (SWALL:Q9S5G4) (245 aa) fasta scores: E(): 4.1e-69, 75.81% id in 244 aa.
 
 
 0.999
hisF
Imidazole glycerol phosphate synthase subunit hisf; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
 
 0.999
hisI
Similar to Escherichia coli histidine biosynthesis bifunctional protein HisIE [includes: phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphatase HisI or hisie or b2026 SWALL:HIS2_ECOLI (SWALL:P06989) (203 aa) fasta scores: E(): 2e-64, 80.09% id in 201 aa; In the N-terminal section; belongs to the PRA-CH family.
 
 
 0.999
ECA2167
Putative inositol monophosphatase; Similar to Rhizobium loti N-amidino-scyllo-inosamine-4-phosphate phosphatase mll6642 SWALL:Q988Q3 (EMBL:AP003009) (239 aa) fasta scores: E(): 3.3e-47, 56.39% id in 211 aa, and to Agrobacterium rhizogenes Riorf69 protein riorf69 SWALL:Q9KWB5 (EMBL:AB039932) (263 aa) fasta scores: E(): 4e-44, 48.3% id in 265 aa.
  
 
 0.975
pheA
Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri P-protein [includes: chorismate mutase and prephenate dehydratase] PheA or b2599 or z3891 or ecs3462 or sf2659 SWALL:PHEA_ECOLI (SWALL:P07022) (386 aa) fasta scores: E(): 1e-115, 76.17% id in 382 aa.
 
 
 0.922
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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