STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cspDCold shock-like protein; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri cold shock-like protein CspD or CspH or b0880 or c1017 or z1117 or ecs0966 or sf0840 SWALL:CSPD_ECOLI (SWALL:P24245) (74 aa) fasta scores: E(): 9.7e-25, 87.32% id in 71 aa. (73 aa)    
Predicted Functional Partners:
hslO
Heat shock protein (33 kDa chaperonin); Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
     
 0.593
lexA
LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
      
 0.569
ECA2658
Hypothetical protein; No significant database matches.
       0.563
ECA2185
Putative membrane protein; Similar to Shigella flexneri orf, conserved hypothetical protein sf1208 SWALL:AAN42821 (EMBL:AE015147) (92 aa) fasta scores: E(): 5e-21, 57.14% id in 91 aa, and to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 hypothetical protein ychh or b1205 or c1663 or z1976 or ecs1710 SWALL:YCHH_ECOLI (SWALL:P31807) (92 aa) fasta scores: E(): 5.8e-21, 57.14% id in 91 aa.
   
    0.562
ptsN
Similar to Escherichia coli, and Shigella flexneri nitrogen regulatory IIA protein PtsN or RpoP SWALL:PTSN_ECOLI (SWALL:P31222) (163 aa) fasta scores: E(): 1.3e-46, 80.12% id in 156 aa, and to Yersinia pestis phosphotransferase system enzyme IIA PtsN SWALL:AAM83751 (EMBL:AE013615) (164 aa) fasta scores: E(): 6.1e-48, 81.01% id in 158 aa.
   
  
 0.560
dadA
D-amino acid dehydrogenase small subunit; Oxidative deamination of D-amino acids; Belongs to the DadA oxidoreductase family.
   
    0.552
recB
Exodeoxyribonuclease V beta chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repai [...]
  
  
 0.549
corC
Similar to Salmonella typhimurium, and Salmonella typhi magnesium and cobalt efflux protein CorC or stm0667 or sty0712 SWALL:CORC_SALTY (SWALL:Q9R874) (292 aa) fasta scores: E(): 1.5e-92, 85.95% id in 292 aa, and to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri magnesium and cobalt efflux protein CorC or b0658 or c0743 or z0807 or ecs0696 or sf0624 SWALL:CORC_ECOLI (SWALL:P77392) (292 aa) fasta scores: E(): 2.6e-92, 85.61% id in 292 aa.
      
 0.545
degP
Protease Do; Similar to Escherichia coli, and Escherichia coli O157:H7 protease Do precursor DegP or HtrA or Ptd or b0161 or z0173 or ecs0165 SWALL:DEGP_ECOLI (SWALL:P09376) (474 aa) fasta scores: E(): 1.3e-102, 70.28% id in 488 aa; Belongs to the peptidase S1C family.
      
 0.496
gst
Glutathione S-transferase; Similar to Escherichia coli, and Escherichia coli O157:H7 glutathione s-transferase Gst or b1635 or z2647 or ecs2344 SWALL:GT_ECOLI (SWALL:P39100) (201 aa) fasta scores: E(): 3.8e-39, 53.23% id in 201 aa; Belongs to the GST superfamily.
   
 
 0.492
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.