STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
bioCBiotin synthesis protein; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (253 aa)    
Predicted Functional Partners:
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
 
  
 0.958
bioD
Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family.
 
  
 0.950
bioH
Putative biotin biosynthesis protein; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
  
 0.934
bioF
8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
 
  
 0.930
fabB
Similar to Escherichia coli, and Escherichia coli O6 3-oxoacyl-[acyl-carrier-protein] synthase I FabB or FabC or b2323 or c2869 SWALL:FABB_ECOLI (SWALL:P14926) (406 aa) fasta scores: E(): 1.3e-137, 92.32% id in 404 aa; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
    
 0.902
cfa3
Cfa-beta-ketoacylsynthase; Similar to Pseudomonas syringae cfa-beta-ketoacylsynthase Cfa3 SWALL:P72239 (EMBL:U56980) (379 aa) fasta scores: E(): 2.7e-75, 56.15% id in 374 aa, and to Streptomyces coelicolor putative 3-oxoacyl-(acyl-carrier-protein) synthase Sco0548 or scf11.28C SWALL:Q9RK62 (EMBL:AL939105) (428 aa) fasta scores: E(): 3.6e-25, 34.45% id in 415 aa; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
    
 0.900
fabF
3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
    
 0.900
ECA2928
3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
    
 0.900
ECA4491
Putative beta-ketoacyl-ACP synthase; Similar to Actinobacillus actinomycetemcomitans beta-ketoacyl-ACP synthase IV FabF SWALL:P70719 (EMBL:D88189) (414 aa) fasta scores: E(): 5.7e-93, 56.52% id in 414 aa, and to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri 3-oxoacyl-[acyl-carrier-protein] synthase II fabf or fabj or b1095 or c1365 or z1734 or ecs1473 or sf1099 SWALL:AAN42718 (EMBL:Z34979) (413 aa) fasta scores: E(): 8.9e-46, 38.74% id in 413 aa; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
    
 0.900
ECA4494
Putative beta-ketoacyl synthase; Similar to Escherichia coli O157:H7 putative 3-oxoacyl-[ACP] synthase z4863 or ecs4338 SWALL:Q8X6K9 (EMBL:AE005571) (389 aa) fasta scores: E(): 2e-98, 69.58% id in 388 aa, and to Vibrio vulnificus 3-oxoacyl-(acyl-carrier-protein) synthase vv10058 SWALL:AAO08600 (EMBL:AE016797) (395 aa) fasta scores: E(): 1.3e-65, 49.48% id in 390 aa; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
    
 0.900
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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