STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ECA2965Putative mandelate racemase / muconate lactonizing enzyme; Similar to Streptomyces coelicolor putative isomerase sco3475 or sce65.11c or sce56.11C SWALL:Q9RKG2 (EMBL:AL939116) (377 aa) fasta scores: E(): 1.1e-43, 39.08% id in 394 aa, and to Oceanobacillus iheyensis hypothetical protein ob2215 SWALL:BAC14171 (EMBL:AP004600) (382 aa) fasta scores: E(): 6.9e-41, 36.36% id in 396 aa. (393 aa)    
Predicted Functional Partners:
dgoK
Similar to Escherichia coli 2-dehydro-3-deoxygalactonokinase DgoK or b3693 SWALL:DGOK_ECOLI (SWALL:P31459) (292 aa) fasta scores: E(): 3.5e-61, 54.76% id in 294 aa.
 
 0.964
dgoA1
DgoA protein [includes: 2-dehydro-3-deoxyphosphogalactonate aldolase; Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy- D-galactonate.
  
  
 
0.898
dgoA2
Similar to the N-terminal region of Escherichia coli DgoA protein [includes: 2-dehydro-3-deoxyphosphogalactonate aldolase; galactonate dehydratase] DgoA or DgoD or b3692 SWALL:DGOA_ECOLI (SWALL:P31458) (587 aa) fasta scores: E(): 1.3e-38, 61.08% id in 203 aa, and similar, over the entire length, to Xanthomonas axonopodis 4-hydroxy-2-oxoglutarate aldolase/2-deydro-3-deoxyphosphogluconate aldolase DgoA or xac1766 SWALL:Q8PLM9 (EMBL:AE011808) (210 aa) fasta scores: E(): 2.8e-38, 56.63% id in 196 aa.
 
   
 0.494
ECA0189
Putative mandelate racemase / muconate lactonizing enzyme; Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.
  
  
 
0.488
rspA
Putative starvation sensing mandelate racemase / muconate lactonizing enzyme; Similar to Escherichia coli starvation sensing protein RspA SWALL:RSPA_ECOLI (SWALL:P38104) (404 aa) fasta scores: E(): 5.7e-163, 92.57% id in 404 aa. Also similar to ECA0189 (36.070% id. in 402 aa overlap).
  
  
 
0.475
panE
2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
   
    0.413
ECA1579
Probable ketopantoate reductase; Similar to Escherichia coli, and Shigella flexneri 2-dehydropantoate 2-reductase PanE or ApbA or b0425 or sf0362 SWALL:PANE_ECOLI (SWALL:P77728) (303 aa) fasta scores: E(): 0.016, 24.29% id in 284 aa, and to Mycobacterium tuberculosis putative 2-dehydropantoate 2-reductase rv2573 or mt2649 or mtcy227.28C SWALL:PANE_MYCTU (SWALL:Q50648) (295 aa) fasta scores: E(): 5.3e-56, 51.2% id in 291 aa. Also similar to ECA1136 (24.101% id in 278 aa overlap).
   
    0.413
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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