| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ECA0270 | ECA3034 | ECA0270 | ECA3034 | Conserved hypothetical protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Putative phosphohydrolase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | 0.944 |
| ECA0270 | cmk | ECA0270 | ECA2592 | Conserved hypothetical protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Cytidylate kinase; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 cytidylate kinase Cmk or MssA or b0910 or c1048 or z1256 or ecs0993 SWALL:KCY_ECOLI (SWALL:P23863) (227 aa) fasta scores: E(): 3.1e-66, 83.55% id in 225 aa. | 0.947 |
| ECA0270 | thyA | ECA0270 | ECA0988 | Conserved hypothetical protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.944 |
| ECA0270 | ushA | ECA0270 | ECA1184 | Conserved hypothetical protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Similar to Escherichia coli protein UshA precursor [includes: UDP-sugar hydrolase and 5'-nucleotidase] UshA or b0480 SWALL:USHA_ECOLI (SWALL:P07024) (550 aa) fasta scores: E(): 1.6e-157, 71.5% id in 551 aa; Belongs to the 5'-nucleotidase family. | 0.944 |
| ECA3034 | ECA0270 | ECA3034 | ECA0270 | Putative phosphohydrolase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | Conserved hypothetical protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.944 |
| ECA3034 | cmk | ECA3034 | ECA2592 | Putative phosphohydrolase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | Cytidylate kinase; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 cytidylate kinase Cmk or MssA or b0910 or c1048 or z1256 or ecs0993 SWALL:KCY_ECOLI (SWALL:P23863) (227 aa) fasta scores: E(): 3.1e-66, 83.55% id in 225 aa. | 0.946 |
| ECA3034 | deoA | ECA3034 | ECA0728 | Putative phosphohydrolase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. | 0.945 |
| ECA3034 | deoD | ECA3034 | ECA0730 | Putative phosphohydrolase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | Purine nucleoside phosphorylase; Similar to Escherichia coli, and Escherichia coli O157:H7 purine nucleoside phosphorylase deoD or Pup or b4384 or z5986 or ecs5343 SWALL:DEOD_ECOLI (SWALL:P09743) (238 aa) fasta scores: E(): 2.1e-80, 89.07% id in 238 aa. | 0.945 |
| ECA3034 | dgt | ECA3034 | ECA3302 | Putative phosphohydrolase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | Deoxyguanosinetriphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily. | 0.953 |
| ECA3034 | dut | ECA3034 | ECA0143 | Putative phosphohydrolase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.951 |
| ECA3034 | gmk | ECA3034 | ECA0040 | Putative phosphohydrolase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.945 |
| ECA3034 | thyA | ECA3034 | ECA0988 | Putative phosphohydrolase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.944 |
| ECA3034 | udp | ECA3034 | ECA0185 | Putative phosphohydrolase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. | 0.944 |
| ECA3034 | ushA | ECA3034 | ECA1184 | Putative phosphohydrolase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | Similar to Escherichia coli protein UshA precursor [includes: UDP-sugar hydrolase and 5'-nucleotidase] UshA or b0480 SWALL:USHA_ECOLI (SWALL:P07024) (550 aa) fasta scores: E(): 1.6e-157, 71.5% id in 551 aa; Belongs to the 5'-nucleotidase family. | 0.958 |
| cmk | ECA0270 | ECA2592 | ECA0270 | Cytidylate kinase; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 cytidylate kinase Cmk or MssA or b0910 or c1048 or z1256 or ecs0993 SWALL:KCY_ECOLI (SWALL:P23863) (227 aa) fasta scores: E(): 3.1e-66, 83.55% id in 225 aa. | Conserved hypothetical protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.947 |
| cmk | ECA3034 | ECA2592 | ECA3034 | Cytidylate kinase; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 cytidylate kinase Cmk or MssA or b0910 or c1048 or z1256 or ecs0993 SWALL:KCY_ECOLI (SWALL:P23863) (227 aa) fasta scores: E(): 3.1e-66, 83.55% id in 225 aa. | Putative phosphohydrolase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | 0.946 |
| cmk | dut | ECA2592 | ECA0143 | Cytidylate kinase; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 cytidylate kinase Cmk or MssA or b0910 or c1048 or z1256 or ecs0993 SWALL:KCY_ECOLI (SWALL:P23863) (227 aa) fasta scores: E(): 3.1e-66, 83.55% id in 225 aa. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.478 |
| cmk | gmk | ECA2592 | ECA0040 | Cytidylate kinase; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 cytidylate kinase Cmk or MssA or b0910 or c1048 or z1256 or ecs0993 SWALL:KCY_ECOLI (SWALL:P23863) (227 aa) fasta scores: E(): 3.1e-66, 83.55% id in 225 aa. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.551 |
| cmk | ushA | ECA2592 | ECA1184 | Cytidylate kinase; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 cytidylate kinase Cmk or MssA or b0910 or c1048 or z1256 or ecs0993 SWALL:KCY_ECOLI (SWALL:P23863) (227 aa) fasta scores: E(): 3.1e-66, 83.55% id in 225 aa. | Similar to Escherichia coli protein UshA precursor [includes: UDP-sugar hydrolase and 5'-nucleotidase] UshA or b0480 SWALL:USHA_ECOLI (SWALL:P07024) (550 aa) fasta scores: E(): 1.6e-157, 71.5% id in 551 aa; Belongs to the 5'-nucleotidase family. | 0.944 |
| deoA | ECA3034 | ECA0728 | ECA3034 | Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. | Putative phosphohydrolase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | 0.945 |