STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prmBConserved hypothetical protein; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. (310 aa)    
Predicted Functional Partners:
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
 
 
 0.892
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
  
 0.759
mepA
Penicillin-insensitive murein endopeptidase; Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus. Belongs to the peptidase M74 family.
     
 0.666
gcvP
Putative glycine cleavage system P protein (glycine dehydrogenase [decarboxylating]); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
     
  0.641
ECA3067
Similar to Yersinia pestis putative membrane protein ypo2753 or y1587 SWALL:Q8ZD39 (EMBL:AJ414153) (268 aa) fasta scores: E(): 2e-74, 73.48% id in 264 aa, and to Salmonella typhimurium, and Salmonella typhi putative permease yfca or stm2382 or sty2614 SWALL:Q8XEQ5 (EMBL:AE008807) (269 aa) fasta scores: E(): 5.2e-72, 71.37% id in 262 aa.
       0.633
dapE
Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily.
 
    0.607
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
     
  0.606
ECA3071
Conserved hypothetical protein; Similar to Escherichia coli, Escherichia coli O6, and Shigella flexneri hypothetical protein yfcn or b2331 or c2877 or sf2406 SWALL:YFCN_ECOLI (SWALL:P77458) (183 aa) fasta scores: E(): 2.2e-54, 73.71% id in 175 aa, and to Salmonella typhimurium, and Salmonella typhi hypothetical protein yfcn or stm2386 or sty2618 SWALL:YFCN_SALTY (SWALL:Q8XFE8) (183 aa) fasta scores: E(): 3e-54, 73.14% id in 175 aa; Belongs to the UPF0115 family.
       0.598
ECA3066
Conserved hypothetical protein; Similar to Salmonella typhimurium putative cytoplasmic protein yfcm or stm2381 SWALL:Q8ZNB1 (EMBL:AE008807) (182 aa) fasta scores: E(): 5.4e-64, 77.9% id in 181 aa, and to Shigella flexneri putative transporting ATPase yfcm or sf2402 SWALL:AAN43915 (EMBL:AE015256) (182 aa) fasta scores: E(): 6.4e-64, 77.9% id in 181 aa.
       0.580
rplL
50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.
   
  
 0.558
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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