STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sixASimilar to Escherichia coli phosphohistidine phosphatase SixA or b2340 SWALL:SIXA_ECOLI (SWALL:P76502) (161 aa) fasta scores: E(): 6.1e-35, 66.02% id in 156 aa. (160 aa)    
Predicted Functional Partners:
rseA
sigma-E factor negative regulator; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases [...]
  
    0.599
glpG
Putative membrane protein; Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
 
     0.572
dsbB
Disulfide bond formation protein B; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family.
  
     0.571
ECA4231
Conserved hypothetical protein; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri protein yife or b3764 or c4686 or z5276 or ecs4699 or sf3840 SWALL:AAN45278 (EMBL:M87049) (112 aa) fasta scores: E(): 2.1e-36, 79.46% id in 112 aa, and to Yersinia pestis hypothetical protein Ypo3903 SWALL:Q8ZAA8 (EMBL:AJ414159) (112 aa) fasta scores: E(): 7.3e-36, 81.25% id in 112 aa.
  
     0.565
thiI
Thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
     0.563
arcB
Similar to Escherichia coli, and Shigella flexneri aerobic respiration control sensor protein ArcB or b3210 or sf3250 SWALL:ARCB_ECOLI (SWALL:P22763) (778 aa) fasta scores: E(): 8.6e-180, 75.88% id in 788 aa, and to Yersinia pestis aerobic respiration control sensor/response regulatory protein ArcB SWALL:Q8ZB69 (EMBL:AJ414157) (778 aa) fasta scores: E(): 3.6e-190, 80.71% id in 788 aa.
 
   
 0.559
ECA3586
Similar to Yersinia pestis hypothetical protein Ypo0652 SWALL:Q8ZI62 (EMBL:AJ414144) (435 aa) fasta scores: E(): 2.2e-84, 51.13% id in 442 aa, and to Escherichia coli hypothetical protein ygif or b3054 SWALL:YGIF_ECOLI (SWALL:P30871) (433 aa) fasta scores: E(): 2.1e-80, 48.86% id in 442 aa.
 
     0.559
nfi
Endonuclease V (pseudogene); 1 probable transmembrane helix predicted for ECA0236 by TMHMM2.0 at aa 102-124.
  
     0.538
ECA2342
Similar to Yersinia pestis hypothetical protein Ypo2159 SWALL:Q8ZEK6 (EMBL:AJ414151) (90 aa) fasta scores: E(): 1.4e-26, 78.88% id in 90 aa, and to Escherichia coli hypothetical protein yeac or b1777 SWALL:YEAC_ECOLI (SWALL:P76231) (90 aa) fasta scores: E(): 1.1e-22, 67.04% id in 88 aa.
  
     0.538
ttK
TetR-family transcriptional regulator; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
  
     0.524
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.