Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
hsdMSubunit M of type I restriction-modification system; Similar to Escherichia coli type I restriction enzyme EcoEI M protein HsdM SWALL:T1ME_ECOLI (SWALL:Q47282) (490 aa) fasta scores: E(): 6.2e-193, 97.55% id in 490 aa, and to Salmonella enterica styski methylase HsdM SWALL:P95732 (EMBL:Y11005) (493 aa) fasta scores: E(): 2e-178, 89.38% id in 490 aa. (490 aa)    
Predicted Functional Partners:
hsdS
Subunit S of type I restriction-modification system; Similar to Escherichia coli type i restriction enzyme EcoEI specificity protein HsdS or Hss SWALL:T1SE_ECOLI (SWALL:P19705) (594 aa) fasta scores: E(): 4.7e-62, 44.05% id in 606 aa, and to Salmonella enterica styski methylase HsdS SWALL:P95733 (EMBL:Y11005) (587 aa) fasta scores: E(): 6.2e-57, 40.95% id in 608 aa.
 
 
 0.996
hsdR
Similar to Escherichia coli type I restriction enzyme EcoEI R protein HsdR or Hsr SWALL:T1RE_ECOLI (SWALL:Q47281) (813 aa) fasta scores: E(): 0, 94.71% id in 813 aa, and to Pseudomonas putida type I restriction-modification system, R subunit hsdr or pp4740 SWALL:AAN70312 (EMBL:AE016791) (787 aa) fasta scores: E(): 3.5e-149, 61.76% id in 803 aa.
 
   
 0.913
NucS
Hypothetical protein; No significant database matches.
 
    0.869
ECA0584
Similar to Bacillus coagulans restriction enzyme bgci alpha subunit bcgiA SWALL:T4BA_BACCO (SWALL:Q07605) (637 aa) fasta scores: E(): 1.3e-46, 31.12% id in 633 aa, and to Staphylococcus aureus bacteriophage phi-42 hypothetical 72.6 kDa protein SWALL:P95687 (EMBL:X94423) (639 aa) fasta scores: E(): 1.9e-42, 30.78% id in 653 aa.
  
     0.725
ruvC
Crossover junction endodeoxyribonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
      
 0.554
queC
Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)); Belongs to the QueC family.
     
 0.509
queE
Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
      
 0.499
lhr
Similar to Escherichia coli probable ATP-dependent helicase Lhr or RhlF or b1653 SWALL:LHR_ECOLI (SWALL:P30015) (1538 aa) fasta scores: E(): 9.6e-156, 57.39% id in 1603 aa, and to Streptomyces coelicolor ATP dependent DNA helicase sco5761 or sc7c7.16C SWALL:O86821 (EMBL:AL939125) (1690 aa) fasta scores: E(): 3.8e-129, 51.11% id in 1479 aa.
  
  
 0.469
folE
GTP cyclohydrolase I; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri GTP cyclohydrolase I FolE or b2153 or c2688 or z3409 or ecs3045 or sf2238 SWALL:GCH1_ECOLI (SWALL:P27511) (221 aa) fasta scores: E(): 9.1e-71, 88.18% id in 220 aa.
      
 0.468
lamB
Maltoporin; Involved in the transport of maltose and maltodextrins. Belongs to the porin LamB (TC 1.B.3) family.
      
 0.464
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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