STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
engAProbable GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (495 aa)    
Predicted Functional Partners:
cmk
Cytidylate kinase; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 cytidylate kinase Cmk or MssA or b0910 or c1048 or z1256 or ecs0993 SWALL:KCY_ECOLI (SWALL:P23863) (227 aa) fasta scores: E(): 3.1e-66, 83.55% id in 225 aa.
  
 0.984
gpsA
Glycerol-3-phosphate dehydrogenase [NAD(P)+]; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri glycerol-3-phosphate dehydrogenase [NAD(P)+] GpsA or b3608 or c4430 or z5035 or ecs4486 or sf3647 SWALL:GPDA_ECOLI (SWALL:P37606) (339 aa) fasta scores: E(): 9.3e-104, 86.26% id in 335 aa; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
  
 0.877
ECA2291
Similar to Yersinia pestis putative RNA pseudouridylate synthase-family protein ypo2213 SWALL:Q8ZEG0 (EMBL:AJ414151) (318 aa) fasta scores: E(): 8.9e-95, 84.58% id in 279 aa, and to Escherichia coli hypothetical protein ycil ycil or b1269 SWALL:YCIL_ECOLI (SWALL:P37765) (291 aa) fasta scores: E(): 2e-92, 79.93% id in 294 aa; Belongs to the pseudouridine synthase RsuA family.
 
  
 0.870
ffh
Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...]
 
  
 0.779
ftsY
Cell division protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
 
   
 0.771
typA
Similar to Escherichia coli GTP-binding protein TypA or BipA or b3871 SWALL:TYPA_ECOLI (SWALL:P32132) (591 aa) fasta scores: E(): 1.1e-189, 90.18% id in 591 aa. Found to be a virulence regulator in an enteropathogenic Escherichia coli (PMID: 9622352).
 
  
 0.754
ECA2440
Similar to Yersinia pestis putative pseudouridine synthase ypo1640 or y1801 SWALL:Q8ZFQ3 (EMBL:AJ414149) (208 aa) fasta scores: E(): 9.5e-61, 69.71% id in 208 aa, and to Salmonella typhimurium putative ribosomal large subunit pseudouridine synthase ymfc or stm1237 SWALL:Q8ZPZ1 (EMBL:AE008754) (221 aa) fasta scores: E(): 4.4e-60, 69.44% id in 216 aa; Belongs to the pseudouridine synthase RsuA family.
 
  
 0.744
rsuA
Ribosomal small subunit pseudouridine synthase; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri ribosomal small subunit pseudouridine synthase A RsuA or b2183 or c2720 or z3442 or ecs3075 or sf2270 SWALL:RSUA_ECOLI (SWALL:P33918) (231 aa) fasta scores: E(): 5.3e-75, 78.26% id in 230 aa; ribosomal small subunit pseudouridine synthase a.
 
  
 0.741
secA
Preprotein translocase SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
 
  
 0.740
ECA4112
Putative octopine/opine/tauropine dehydrogenase; Similar to Arthrobacter sp. opine dehydrogenase Odh SWALL:ODH_ARTSP (SWALL:Q44297) (359 aa) fasta scores: E(): 0.53, 26.42% id in 352 aa, and to Rhizobium fredii Y4xO SWALL:Q8RQB9 (EMBL:AF229441) (406 aa) fasta scores: E(): 2.7e-78, 54.83% id in 372 aa, and to Haliotis discus hannai tauropine dehydrogenase TadH SWALL:Q8N0N9 (EMBL:AB085184) (405 aa) fasta scores: E(): 6.1e-16, 24.33% id in 374 aa, and to Pecten maximus octopine dehydrogenase Odh1 SWALL:Q9BHM6 (EMBL:AJ237916) (399 aa) fasta scores: E(): 1.3e-12, 24.39% id in 369 aa.
  
  
 0.718
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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