STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
icsUNifU-like protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (128 aa)    
Predicted Functional Partners:
iscS
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
 
 0.994
hscB
Chaperone protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
 
 0.992
nifS
Cysteine desulfurase; Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.
 
 0.977
fdx
Ferredoxin, 2Fe-2S; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri ferredoxin, 2fe-2s Fdx or b2525 or z3792 or ecs3391 or sf2572 SWALL:AAN44071 (EMBL:M88654) (111 aa) fasta scores: E(): 6.7e-39, 84.68% id in 111 aa.
 
 0.968
hscA
Chaperone protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU.
 
 0.967
iscR
Putative transcriptional regulator; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins.
  
  
 0.929
iscA
Conserved hypothetical protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.
 
 
 0.902
csdA
Similar to Escherichia coli cysteine sulfinate desulfinase CsdA or b2810 SWALL:CSDA_ECOLI (SWALL:Q46925) (401 aa) fasta scores: E(): 1.6e-104, 69.82% id in 401 aa, and to Salmonella typhimurium putative selenocysteine lyase csda or stm2984 SWALL:Q8ZMC3 (EMBL:AE008836) (401 aa) fasta scores: E(): 3.2e-101, 67.83% id in 401 aa.
  
 0.898
sufS
Selenocysteine lyase; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo.
  
 0.898
ECA3231
Conserved hypothetical protein; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri hypothetical protein yfhj or b2524 or z3791 or ecs3390 or sf2571 SWALL:AAN44070 (EMBL:M88654) (66 aa) fasta scores: E(): 3.5e-23, 83.33% id in 66 aa, and to Yersinia pestis hypothetical protein ypo2890 or y1341 SWALL:Q8ZCS7 (EMBL:AJ414154) (66 aa) fasta scores: E(): 6.1e-20, 76.56% id in 64 aa.
 
 
 0.883
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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