STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hmpXFlavohemoprotein; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. (396 aa)    
Predicted Functional Partners:
ytfE
Conserved hypothetical protein; Di-iron-containing protein involved in the repair of iron- sulfur clusters damaged by oxidative and nitrosative stress conditions.
  
  
 0.958
norV
Anaerobic nitric oxide reductase flavorubredoxin; Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase; In the N-terminal section; belongs to the zinc metallo- hydrolase group 3 family.
  
  
 0.803
nasB
Similar to Klebsiella pneumoniae nitrite reductase [NAD(P)H] large subunit NasB SWALL:NIRB_KLEPN (SWALL:Q06458) (957 aa) fasta scores: E(): 0, 70.89% id in 962 aa; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
  
  
 0.783
hcp
Prismane protein homolog (hybrid-cluster protein); Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
  
  
 0.778
nrfA
Cytochrome c552 precursor; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family.
     
 0.725
nsrR
Conserved hypothetical protein; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity.
 
   
 0.716
norW
Nitric oxide reductase FlrD-NAD(+) reductase; One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase.
  
  
 0.688
nirB
Similar to Escherichia coli nitrite reductase [NAD(P)H] large subunit NirB or b3365 SWALL:NIRB_ECOLI (SWALL:P08201) (847 aa) fasta scores: E(): 0, 80.45% id in 844 aa; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
  
  
 0.688
ahpF
Similar to Escherichia coli alkyl hydroperoxide reductase subunit F AhpF or b0606 SWALL:AHPF_ECOLI (SWALL:P35340) (521 aa) fasta scores: E(): 3.1e-149, 78.09% id in 525 aa; EC number 1.6.4.-.
      
 0.687
sodA
Manganese superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
     
 0.665
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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