| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| lepA | lepB | ECA3280 | ECA3279 | GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | Similar to Escherichia coli signal peptidase I LepB or b2568 SWALL:LEP_ECOLI (SWALL:P00803) (324 aa) fasta scores: E(): 4.7e-93, 69.75% id in 324 aa; Belongs to the peptidase S26 family. | 0.978 |
| lepA | rplB | ECA3280 | ECA4028 | GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 0.940 |
| lepA | rplM | ECA3280 | ECA0306 | GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.972 |
| lepA | rplS | ECA3280 | ECA3356 | GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.937 |
| lepA | rplT | ECA3280 | ECA2419 | GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | 0.944 |
| lepA | rpmA | ECA3280 | ECA0691 | GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 50S ribosomal subunit protein L27; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri 50S ribosomal protein l27 RpmA SWALL:RL27_ECOLI (SWALL:P02427) (84 aa) fasta scores: E(): 1.7e-28, 89.28% id in 84 aa; Belongs to the bacterial ribosomal protein bL27 family. | 0.937 |
| lepA | rpsB | ECA3280 | ECA1031 | GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 30S ribosomal protein S2; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 30s ribosomal protein s2 RpsB or b0169 or c0204 or z0180 or ecs0171 SWALL:RS2_ECOLI (SWALL:P02351) (240 aa) fasta scores: E(): 4.5e-85, 92.5% id in 240 aa; Belongs to the universal ribosomal protein uS2 family. | 0.952 |
| lepA | rpsD | ECA3280 | ECA4007 | GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 30S ribosomal subunit protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. | 0.974 |
| lepA | rpsI | ECA3280 | ECA0307 | GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 30S ribosomal protein S9; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 30s ribosomal protein S9 RpsI SWALL:RS9_ECOLI (SWALL:P02363) (129 aa) fasta scores: E(): 1.1e-43, 96.12% id in 129 aa, and to Salmonella typhimurium, and Salmonella typhi 30S ribosomal protein S9 RpsI SWALL:RS9_SALTY (SWALL:Q8XFX5) (129 aa) fasta scores: E(): 3.3e-44, 96.89% id in 129 aa; Belongs to the universal ribosomal protein uS9 family. | 0.960 |
| lepA | rpsL | ECA3280 | ECA4038 | GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 30S ribosomal subunit protein S12; With S4 and S5 plays an important role in translational accuracy. | 0.942 |
| lepB | lepA | ECA3279 | ECA3280 | Similar to Escherichia coli signal peptidase I LepB or b2568 SWALL:LEP_ECOLI (SWALL:P00803) (324 aa) fasta scores: E(): 4.7e-93, 69.75% id in 324 aa; Belongs to the peptidase S26 family. | GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.978 |
| rplB | lepA | ECA4028 | ECA3280 | 50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.940 |
| rplB | rplM | ECA4028 | ECA0306 | 50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.999 |
| rplB | rplS | ECA4028 | ECA3356 | 50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.997 |
| rplB | rplT | ECA4028 | ECA2419 | 50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | 0.997 |
| rplB | rpmA | ECA4028 | ECA0691 | 50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 50S ribosomal subunit protein L27; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri 50S ribosomal protein l27 RpmA SWALL:RL27_ECOLI (SWALL:P02427) (84 aa) fasta scores: E(): 1.7e-28, 89.28% id in 84 aa; Belongs to the bacterial ribosomal protein bL27 family. | 0.993 |
| rplB | rpsB | ECA4028 | ECA1031 | 50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 30S ribosomal protein S2; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 30s ribosomal protein s2 RpsB or b0169 or c0204 or z0180 or ecs0171 SWALL:RS2_ECOLI (SWALL:P02351) (240 aa) fasta scores: E(): 4.5e-85, 92.5% id in 240 aa; Belongs to the universal ribosomal protein uS2 family. | 0.998 |
| rplB | rpsD | ECA4028 | ECA4007 | 50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 30S ribosomal subunit protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. | 0.999 |
| rplB | rpsI | ECA4028 | ECA0307 | 50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 30S ribosomal protein S9; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 30s ribosomal protein S9 RpsI SWALL:RS9_ECOLI (SWALL:P02363) (129 aa) fasta scores: E(): 1.1e-43, 96.12% id in 129 aa, and to Salmonella typhimurium, and Salmonella typhi 30S ribosomal protein S9 RpsI SWALL:RS9_SALTY (SWALL:Q8XFX5) (129 aa) fasta scores: E(): 3.3e-44, 96.89% id in 129 aa; Belongs to the universal ribosomal protein uS9 family. | 0.998 |
| rplB | rpsL | ECA4028 | ECA4038 | 50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 30S ribosomal subunit protein S12; With S4 and S5 plays an important role in translational accuracy. | 0.999 |
