STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rseBsigma-E factor regulatory protein; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri sigma-E factor regulatory protein RseB precursor RseB or b2571 or z3853 or ecs3437 or sf2633 SWALL:RSEB_ECOLI (SWALL:P46186) (318 aa) fasta scores: E(): 3.1e-69, 57.36% id in 319 aa. (320 aa)    
Predicted Functional Partners:
rseA
sigma-E factor negative regulator; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases [...]
 
     0.936
rseC
Similar to Escherichia coli sigma-E factor regulatory protein RseC or b2570 SWALL:RSEC_ECOLI (SWALL:P46187) (159 aa) fasta scores: E(): 1.4e-23, 49.66% id in 149 aa, and to Yersinia enterocolitica RseC protein rseC SWALL:Q8KQC9 (EMBL:AY098586) (153 aa) fasta scores: E(): 7.2e-27, 55.24% id in 143 aa.
 
   
 0.888
rpoE
RNA polymerase sigma-E factor; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri RNA polymerase sigma-E factor RpoE or SigE or b2573 or c3097 or z3855 or ecs3439 or sf2635 SWALL:RPOE_ECOLI (SWALL:P34086) (191 aa) fasta scores: E(): 6.8e-68, 92.14% id in 191 aa; Belongs to the sigma-70 factor family. ECF subfamily.
 
     0.776
ECA3341
Similar to Yersinia pestis hypothetical protein ypo1080 or y3096 SWALL:AAM86646 (EMBL:AJ414146) (239 aa) fasta scores: E(): 6.6e-62, 61.86% id in 236 aa, and to Salmonella typhimurium putative sam-dependent methyltransferase yafs or stm0262 SWALL:Q8ZRM1 (EMBL:AE008707) (240 aa) fasta scores: E(): 6.6e-60, 59.07% id in 237 aa.
  
     0.743
seqA
Putative negative regulator of replication initiation; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
  
     0.715
lapA
Putative membrane protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family.
  
     0.685
ECA2748
Similar to Yersinia pestis hypothetical protein Ypo1261 SWALL:Q8ZGM6 (EMBL:AJ414147) (75 aa) fasta scores: E(): 4.5e-22, 85.52% id in 76 aa, and to Salmonella typhimurium, and Salmonella typhi putative cytoplasmic protein yejl or stm2227 or sty2465 SWALL:Q8XEL6 (EMBL:AE008799) (75 aa) fasta scores: E(): 1.6e-19, 78.94% id in 76 aa; Belongs to the UPF0352 family.
  
     0.676
lptC
Putative exported protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.
  
     0.668
nlpB
Lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
  
     0.598
smpA
Putative outer membrane lipopotein (small protein A); Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
  
     0.595
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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