STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rseAsigma-E factor negative regulator; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases [...] (215 aa)    
Predicted Functional Partners:
rpoE
RNA polymerase sigma-E factor; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri RNA polymerase sigma-E factor RpoE or SigE or b2573 or c3097 or z3855 or ecs3439 or sf2635 SWALL:RPOE_ECOLI (SWALL:P34086) (191 aa) fasta scores: E(): 6.8e-68, 92.14% id in 191 aa; Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.987
rseB
sigma-E factor regulatory protein; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri sigma-E factor regulatory protein RseB precursor RseB or b2571 or z3853 or ecs3437 or sf2633 SWALL:RSEB_ECOLI (SWALL:P46186) (318 aa) fasta scores: E(): 3.1e-69, 57.36% id in 319 aa.
 
     0.936
rseC
Similar to Escherichia coli sigma-E factor regulatory protein RseC or b2570 SWALL:RSEC_ECOLI (SWALL:P46187) (159 aa) fasta scores: E(): 1.4e-23, 49.66% id in 149 aa, and to Yersinia enterocolitica RseC protein rseC SWALL:Q8KQC9 (EMBL:AY098586) (153 aa) fasta scores: E(): 7.2e-27, 55.24% id in 143 aa.
 
  
 0.914
sspB
Stringent starvation protein B; Similar to Escherichia coli, and Escherichia coli O157:H7 stringent starvation protein B SspB or b3228 or z4586 or ecs4101 SWALL:SSPB_ECOLI (SWALL:P25663) (165 aa) fasta scores: E(): 3e-39, 71.42% id in 168 aa.
    
 
 0.831
degS
Exported protease; Similar to Escherichia coli, and Escherichia coli O157:H7 protease DegS precursor DegS or HhoB or HtrH or b3235 or z4594 or ecs4108 SWALL:DEGS_ECOLI (SWALL:P31137) (355 aa) fasta scores: E(): 9.1e-73, 58.51% id in 364 aa.
  
 
 0.816
lapA
Putative membrane protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family.
  
     0.760
lptC
Putative exported protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.
  
     0.751
ECA0057
Similar to Escherichia coli probable RNA polymerase sigma factor FecI or b4293 SWALL:FECI_ECOLI (SWALL:P23484) (173 aa) fasta scores: E(): 2.2e-25, 46.38% id in 166 aa; Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.733
ECA0813
RNA polymerase sigma factor; Similar to Bordetella avium RhuI SWALL:Q8L1U9 (EMBL:AY095952) (168 aa) fasta scores: E(): 5.1e-26, 45% id in 160 aa, and to Escherichia coli probable RNA polymerase sigma factor feci feci or b4293 SWALL:FECI_ECOLI (SWALL:P23484) (173 aa) fasta scores: E(): 2.1e-22, 43.94% id in 157 aa; Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.733
fecI
Similar to Escherichia coli probable RNA polymerase sigma factor FecI or b4293 SWALL:FECI_ECOLI (SWALL:P23484) (173 aa) fasta scores: E(): 1.1e-48, 78.61% id in 173 aa, and to Shigella flexneri 2a FecI SWALL:AAL08458 (EMBL:AF326777) (173 aa) fasta scores: E(): 1.1e-48, 78.61% id in 173 aa; Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.733
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.