Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ECA3346Similar to Yersinia pestis hypothetical protein ypo3276 or y0913 SWALL:Q8ZBV8 (EMBL:AJ414156) (243 aa) fasta scores: E(): 1.6e-62, 66.25% id in 240 aa, and to Salmonella typhi hypothetical protein Sty2850 SWALL:Q8Z4J1 (EMBL:AL627276) (243 aa) fasta scores: E(): 9.7e-62, 64.16% id in 240 aa; Belongs to the multicopper oxidase YfiH/RL5 family. (241 aa)    
Predicted Functional Partners:
hpt
Similar to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt or stm0170 SWALL:HPRT_SALTY (SWALL:O33799) (178 aa) fasta scores: E(): 1.2e-54, 86.2% id in 174 aa, and to Escherichia coli, Escherichia coli O6, and Shigella flexneri hypoxanthine phosphoribosyltransferase Hpt or b0125 or c0154 or sf0122 SWALL:HPRT_ECOLI (SWALL:P36766) (178 aa) fasta scores: E(): 2.4e-54, 84.48% id in 174 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
  0.954
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
    
  0.948
mtn
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulatio [...]
    
 0.947
gpt
Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
    
  0.947
ECA1019
Lysine decarboxylase family protein; Similar to Salmonella typhimurium putative nucleotide binding ygdh or stm2969 SWALL:Q8ZMD2 (EMBL:AE008836) (454 aa) fasta scores: E(): 4.8e-158, 86.78% id in 454 aa, and to Yersinia pestis hypothetical protein ypo1033 or y3148 SWALL:AAM86698 (EMBL:AJ414146) (454 aa) fasta scores: E(): 2e-157, 86.12% id in 454 aa.
     
 0.946
amn
AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.
    
 0.945
add
Similar to Escherichia coli adenosine deaminase Add or b1623 SWALL:ADD_ECOLI (SWALL:P22333) (333 aa) fasta scores: E(): 2.2e-89, 71.77% id in 333 aa; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
    
  0.945
mtnA
Putative translation initiation factor EIF-2B; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
    
  0.945
ECA0053
Putative phosphodiesterase; Similar to Vibrio cholerae 2`,3`-cyclic-nucleotide 2`-phosphodiesterase, putative vc2416 SWALL:Q9KPF2 (EMBL:AE004311) (634 aa) fasta scores: E(): 9.2e-161, 66.4% id in 634 aa; Belongs to the 5'-nucleotidase family.
     
  0.944
expI
Similar to Erwinia carotovora autoinducer synthesis protein CarI or HslI SWALL:CARI_ERWCA (SWALL:P33880) (216 aa) fasta scores: E(): 1.1e-85, 97.22% id in 216 aa, and to Erwinia carotovora autoinducer synthesis protein ExpI SWALL:EXPI_ERWCA (SWALL:P33882) (217 aa) fasta scores: E(): 9.2e-65, 72.94% id in 207 aa, and to Erwinia chrysanthemi AhlI SWALL:Q8KUJ8 (EMBL:AF448800) (212 aa) fasta scores: E(): 6.5e-54, 62.26% id in 212 aa.
     
  0.944
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
Server load: high (98%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.