STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ECA3361Similar to Yersinia pestis putative membrane protein ypo3297 or y0891 SWALL:Q8ZBU5 (EMBL:AJ414156) (297 aa) fasta scores: E(): 4.5e-81, 75.57% id in 262 aa, and to Salmonella typhimurium CorE SWALL:Q9X619 (EMBL:AF130857) (288 aa) fasta scores: E(): 3.6e-78, 72.72% id in 264 aa. (264 aa)    
Predicted Functional Partners:
dsbC
Thiol:disulfide interchange protein; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily.
 
     0.676
ECA1145
Similar to Yersinia pestis putative lipoprotein ypo3161 or y1024 SWALL:AAM84605 (EMBL:AJ414155) (192 aa) fasta scores: E(): 7.8e-54, 80.2% id in 192 aa, and to Salmonella typhi putative lipoprotein sty0487 SWALL:Q8Z8V2 (EMBL:AL627266) (192 aa) fasta scores: E(): 2.3e-47, 68.75% id in 192 aa.
  
     0.667
smpA
Putative outer membrane lipopotein (small protein A); Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
  
    0.622
lapA
Putative membrane protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family.
  
     0.603
ffh
Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...]
       0.600
ECA3341
Similar to Yersinia pestis hypothetical protein ypo1080 or y3096 SWALL:AAM86646 (EMBL:AJ414146) (239 aa) fasta scores: E(): 6.6e-62, 61.86% id in 236 aa, and to Salmonella typhimurium putative sam-dependent methyltransferase yafs or stm0262 SWALL:Q8ZRM1 (EMBL:AE008707) (240 aa) fasta scores: E(): 6.6e-60, 59.07% id in 237 aa.
  
     0.573
holA
Similar to Escherichia coli DNA polymerase III, delta subunit HolA or b0640 SWALL:HOLA_ECOLI (SWALL:P28630) (343 aa) fasta scores: E(): 6.2e-94, 69.79% id in 341 aa.
  
     0.560
rseA
sigma-E factor negative regulator; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases [...]
  
     0.555
crl
Curlin genes transcriptional activator; Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32; Belongs to the Crl family.
  
     0.552
ECA2319
Similar to Yersinia pestis hypothetical protein Ypo2187 SWALL:Q8ZEI3 (EMBL:AJ414151) (107 aa) fasta scores: E(): 2e-40, 91.58% id in 107 aa, and to Salmonella typhi hypothetical protein Sty1311 SWALL:Q8Z7E5 (EMBL:AL627269) (109 aa) fasta scores: E(): 1.6e-39, 90.65% id in 107 aa; Belongs to the UPF0263 family.
  
     0.531
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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