STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
luxSAutoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)    
Predicted Functional Partners:
mtn
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulatio [...]
 
 
 0.992
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.947
metC
Similar to Escherichia coli cystathionine beta-lyase MetC or b3008 SWALL:METC_ECOLI (SWALL:P06721) (395 aa) fasta scores: E(): 8.3e-124, 73.85% id in 394 aa.
 
 
 0.946
metB
Similar to Escherichia coli cystathionine gamma-synthase MetB or b3939 SWALL:METB_ECOLI (SWALL:P00935) (386 aa) fasta scores: E(): 3.8e-129, 87.01% id in 385 aa.
 
 
 0.946
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
    
 0.941
metE-2
5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Similar to Pseudomonas putida MetE SWALL:Q9AF89 (EMBL:AF363277) (361 aa) fasta scores: E(): 1.6e-114, 82.94% id in 340 aa, and to Agrobacterium tumefaciens 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase MetE or atu3823 or agr_l_2018 SWALL:Q8U9A5 (EMBL:AE009313) (342 aa) fasta scores: E(): 3.4e-124, 90.29% id in 340 aa.
    
 0.939
ECA1113
Putative methionine synthase; Similar to Bradyrhizobium japonicum Bll5948 protein bll5948 SWALL:BAC51213 (EMBL:AP005956) (372 aa) fasta scores: E(): 7.6e-92, 59.45% id in 370 aa, and to Listeria innocua hypothetical protein Lin0838 lin0838 SWALL:Q92DH5 (EMBL:AL596166) (367 aa) fasta scores: E(): 1.8e-84, 55.97% id in 368 aa.
 
  
 0.933
ECA4113
Similar to Streptomyces venezuelae cystathionine beta-synthase cbssV SWALL:Q9EYM7 (EMBL:AF319543) (463 aa) fasta scores: E(): 1.5e-28, 36.81% id in 326 aa, and to Rhizobium fredii Y4xP SWALL:Q8RQB8 (EMBL:AF229441) (336 aa) fasta scores: E(): 1.6e-81, 69.06% id in 333 aa.
  
 
 0.926
mmuM
Similar to Escherichia coli homocysteine S-methyltransferase MmuM or b0261 SWALL:MMUM_ECOLI (SWALL:Q47690) (310 aa) fasta scores: E(): 2e-82, 68.85% id in 305 aa.
     
 0.917
ECA0820
Similar to Emericella nidulans O-acetyl-L-homoserine sulfhydrylase CysD SWALL:O13387 (EMBL:AF029318) (437 aa) fasta scores: E(): 2.6e-79, 52.47% id in 425 aa, and to Shewanella oneidensis O-acetylhomoserine so1095 SWALL:AAN54166 (EMBL:AE015554) (430 aa) fasta scores: E(): 3.2e-138, 85.21% id in 426 aa.
     
 0.909
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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