STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ECA3400DnaG primase-like protein; Similar to Photorhabdus luminescens DnaG primase-like DnaG SWALL:AAN64202 (EMBL:AY144117) (925 aa) fasta scores: E(): 5.1e-145, 74.15% id in 921 aa, and to the C-terminal region of Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri DNA primase DnaG or DnaP or ParB or b3066 or z4419 or ecs3949 or sf3107 SWALL:PRIM_ECOLI (SWALL:P02923) (581 aa) fasta scores: E(): 9.7e-14, 29.11% id in 395 aa. Also similar to ECA3390, (82.939% id), ECA3407 (86.812% id), ECA3416 (86.812% id), ECA4282 (84.394% id), and to ECA4291 (84.394% id). (963 aa)    
Predicted Functional Partners:
ECA3399
Probable integrase/recombinase; Similar to Photorhabdus luminescens Int SWALL:AAN64203 (EMBL:AY144117) (465 aa) fasta scores: E(): 1.9e-79, 63.22% id in 329 aa, and to Ralstonia solanacearum probable integrase/recombinase protein rsp0090 or rs05531 SWALL:Q8XTL6 (EMBL:AL646076) (347 aa) fasta scores: E(): 4.1e-52, 48.28% id in 321 aa. Also similar to ECA3389 (93.824% id), ECA3406 (93.003% id), ECA3415 (93.003% id), ECA4283 (66.477% id), ECA4292 (66.477% id); Belongs to the 'phage' integrase family.
 
     0.776
ECA0519
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily.
 
 0.666
topB
Similar to Pseudomonas aeruginosa putative DNA topoisomerase III TopB SWALL:AAN62194 (EMBL:AF440523) (676 aa) fasta scores: E(): 7.1e-127, 46.77% id in 667 aa, and to Salmonella typhi topoisomerase B TopB or sty4530 SWALL:Q9RHF5 (EMBL:AF000001) (664 aa) fasta scores: E(): 2.3e-171, 61.04% id in 670 aa.
  
  
 0.634
priB
Primosomal replication protein N; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family.
   
 
 0.629
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
  
  
 
0.627
ECA2754
Putative prophage primase; Similar to Escherichia coli O157:H7 alpha replication protein of prophage cp-933i z0339 or ecs0303 SWALL:Q8X7I5 (EMBL:AE005204) (796 aa) fasta scores: E(): 1.3e-10, 28.27% id in 633 aa, and to Pasteurella multocida hypothetical protein Pm1782 SWALL:Q9CK52 (EMBL:AE006215) (725 aa) fasta scores: E(): 9.7e-95, 45.25% id in 590 aa, and to Bacteriophage P4 DNA primase SWALL:Q8LTT9 (EMBL:AF509493) (362 aa) fasta scores: E(): 2.3e-41, 47.26% id in 347 aa.
    
  0.613
dnaB
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily.
  
 0.613
topB-2
DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...]
  
  
 0.569
engA
Probable GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
   
  
 0.556
tonB
TonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.
   
  
 0.545
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.