| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ECA2649 | ahpC | ECA2649 | ECA3942 | Thioredoxin reductase. | Alkyl hydroperoxide reductase C22 protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. | 0.892 |
| ECA2649 | grpE | ECA2649 | ECA0842 | Thioredoxin reductase. | Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...] | 0.448 |
| ECA2649 | trxC | ECA2649 | ECA3517 | Thioredoxin reductase. | Thioredoxin 2; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri thioredoxin 2 TrxC or b2582 or c3107 or z3867 or ecs3448 or sf2644 SWALL:THI2_ECOLI (SWALL:P33636) (139 aa) fasta scores: E(): 1.5e-43, 74.81% id in 139 aa; Belongs to the thioredoxin family. | 0.808 |
| ECA3519 | trxC | ECA3519 | ECA3517 | Putative acyl-CoA synthetase; Similar to Yersinia pestis putative acetyltransferase ypo3272 SWALL:Q8ZBW2 (EMBL:AJ414156) (880 aa) fasta scores: E(): 0, 79.56% id in 881 aa, and to Escherichia coli hypothetical protein yfiq or b2584 SWALL:YFIQ_ECOLI (SWALL:P76594) (886 aa) fasta scores: E(): 0, 76.84% id in 881 aa. | Thioredoxin 2; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri thioredoxin 2 TrxC or b2582 or c3107 or z3867 or ecs3448 or sf2644 SWALL:THI2_ECOLI (SWALL:P33636) (139 aa) fasta scores: E(): 1.5e-43, 74.81% id in 139 aa; Belongs to the thioredoxin family. | 0.527 |
| UspE | clpP | ECA2206 | ECA1148 | Similar to Salmonella typhimurium putative universal stress protein ydaa or stm1661 SWALL:Q8ZP84 (EMBL:AE008773) (315 aa) fasta scores: E(): 3e-104, 81.58% id in 315 aa, and to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri protein ydaa or b1333 or c1806 or z2435 or ecs1914 or sf1837 SWALL:AAN43399 (EMBL:AE000231) (325 aa) fasta scores: E(): 3.6e-102, 80% id in 315 aa. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.507 |
| UspE | katB | ECA2206 | ECA1909 | Similar to Salmonella typhimurium putative universal stress protein ydaa or stm1661 SWALL:Q8ZP84 (EMBL:AE008773) (315 aa) fasta scores: E(): 3e-104, 81.58% id in 315 aa, and to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri protein ydaa or b1333 or c1806 or z2435 or ecs1914 or sf1837 SWALL:AAN43399 (EMBL:AE000231) (325 aa) fasta scores: E(): 3.6e-102, 80% id in 315 aa. | Catalase-peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. | 0.532 |
| UspE | trxC | ECA2206 | ECA3517 | Similar to Salmonella typhimurium putative universal stress protein ydaa or stm1661 SWALL:Q8ZP84 (EMBL:AE008773) (315 aa) fasta scores: E(): 3e-104, 81.58% id in 315 aa, and to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri protein ydaa or b1333 or c1806 or z2435 or ecs1914 or sf1837 SWALL:AAN43399 (EMBL:AE000231) (325 aa) fasta scores: E(): 3.6e-102, 80% id in 315 aa. | Thioredoxin 2; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri thioredoxin 2 TrxC or b2582 or c3107 or z3867 or ecs3448 or sf2644 SWALL:THI2_ECOLI (SWALL:P33636) (139 aa) fasta scores: E(): 1.5e-43, 74.81% id in 139 aa; Belongs to the thioredoxin family. | 0.508 |
| ahpC | ECA2649 | ECA3942 | ECA2649 | Alkyl hydroperoxide reductase C22 protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. | Thioredoxin reductase. | 0.892 |
| ahpC | dps | ECA3942 | ECA2767 | Alkyl hydroperoxide reductase C22 protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. | DNA protection during starvation protein; During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. | 0.636 |
| ahpC | grpE | ECA3942 | ECA0842 | Alkyl hydroperoxide reductase C22 protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. | Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...] | 0.535 |
| ahpC | trxC | ECA3942 | ECA3517 | Alkyl hydroperoxide reductase C22 protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. | Thioredoxin 2; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri thioredoxin 2 TrxC or b2582 or c3107 or z3867 or ecs3448 or sf2644 SWALL:THI2_ECOLI (SWALL:P33636) (139 aa) fasta scores: E(): 1.5e-43, 74.81% id in 139 aa; Belongs to the thioredoxin family. | 0.576 |
| clpP | UspE | ECA1148 | ECA2206 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Similar to Salmonella typhimurium putative universal stress protein ydaa or stm1661 SWALL:Q8ZP84 (EMBL:AE008773) (315 aa) fasta scores: E(): 3e-104, 81.58% id in 315 aa, and to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri protein ydaa or b1333 or c1806 or z2435 or ecs1914 or sf1837 SWALL:AAN43399 (EMBL:AE000231) (325 aa) fasta scores: E(): 3.6e-102, 80% id in 315 aa. | 0.507 |
| clpP | grpE | ECA1148 | ECA0842 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...] | 0.737 |
| clpP | katB | ECA1148 | ECA1909 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Catalase-peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. | 0.554 |
| clpP | trxC | ECA1148 | ECA3517 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Thioredoxin 2; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri thioredoxin 2 TrxC or b2582 or c3107 or z3867 or ecs3448 or sf2644 SWALL:THI2_ECOLI (SWALL:P33636) (139 aa) fasta scores: E(): 1.5e-43, 74.81% id in 139 aa; Belongs to the thioredoxin family. | 0.520 |
| dps | ahpC | ECA2767 | ECA3942 | DNA protection during starvation protein; During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. | Alkyl hydroperoxide reductase C22 protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. | 0.636 |
| dps | trxC | ECA2767 | ECA3517 | DNA protection during starvation protein; During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. | Thioredoxin 2; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri thioredoxin 2 TrxC or b2582 or c3107 or z3867 or ecs3448 or sf2644 SWALL:THI2_ECOLI (SWALL:P33636) (139 aa) fasta scores: E(): 1.5e-43, 74.81% id in 139 aa; Belongs to the thioredoxin family. | 0.595 |
| grpE | ECA2649 | ECA0842 | ECA2649 | Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...] | Thioredoxin reductase. | 0.448 |
| grpE | ahpC | ECA0842 | ECA3942 | Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...] | Alkyl hydroperoxide reductase C22 protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. | 0.535 |
| grpE | clpP | ECA0842 | ECA1148 | Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...] | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.737 |