STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trxCThioredoxin 2; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri thioredoxin 2 TrxC or b2582 or c3107 or z3867 or ecs3448 or sf2644 SWALL:THI2_ECOLI (SWALL:P33636) (139 aa) fasta scores: E(): 1.5e-43, 74.81% id in 139 aa; Belongs to the thioredoxin family. (139 aa)    
Predicted Functional Partners:
ECA2649
Thioredoxin reductase.
 
 0.808
katB
Catalase-peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily.
   
 
 0.652
grxA
Glutaredoxin 1; Similar to Escherichia coli, and Shigella flexneri glutaredoxin 1 GrxA or Grx or b0849 or sf0802 SWALL:GLR1_ECOLI (SWALL:P00277) (85 aa) fasta scores: E(): 6e-21, 69.88% id in 83 aa.
  
  
 0.628
dps
DNA protection during starvation protein; During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.
   
  
 0.595
putA
Bifunctional PutA protein [includes: proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family.
    
 
 0.593
ahpC
Alkyl hydroperoxide reductase C22 protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
  
 
 0.576
ECA3519
Putative acyl-CoA synthetase; Similar to Yersinia pestis putative acetyltransferase ypo3272 SWALL:Q8ZBW2 (EMBL:AJ414156) (880 aa) fasta scores: E(): 0, 79.56% id in 881 aa, and to Escherichia coli hypothetical protein yfiq or b2584 SWALL:YFIQ_ECOLI (SWALL:P76594) (886 aa) fasta scores: E(): 0, 76.84% id in 881 aa.
 
   
 0.527
clpP
ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
   
 
 0.520
grpE
Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...]
 
  
 0.508
UspE
Similar to Salmonella typhimurium putative universal stress protein ydaa or stm1661 SWALL:Q8ZP84 (EMBL:AE008773) (315 aa) fasta scores: E(): 3e-104, 81.58% id in 315 aa, and to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri protein ydaa or b1333 or c1806 or z2435 or ecs1914 or sf1837 SWALL:AAN43399 (EMBL:AE000231) (325 aa) fasta scores: E(): 3.6e-102, 80% id in 315 aa.
   
 
 0.508
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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