STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ECA3523Similar to Yersinia pestis hypothetical protein ypo1074 or y3103 SWALL:Q8ZH37 (EMBL:AJ414146) (188 aa) fasta scores: E(): 1.8e-57, 79.03% id in 186 aa, and to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri hypothetical protein yaed or b0200 or z0212 or ecs0202 or sf0191 SWALL:AAN41853 (EMBL:D15061) (191 aa) fasta scores: E(): 2.8e-57, 80.43% id in 184 aa. (187 aa)    
Predicted Functional Partners:
lpcA
Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
  
 0.988
rfaE
ADP-heptose synthase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family.
  
 0.984
diaA
Putative phosphoheptose isomerase; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. Belongs to the SIS family. DiaA subfamily.
  
 0.968
waaF
Similar to Escherichia coli ADP-heptose--LPS heptosyltransferase II RfaF or WaaF or b3620 SWALL:RFAF_ECOLI (SWALL:P37692) (348 aa) fasta scores: E(): 6.2e-108, 74.41% id in 344 aa, and to Serratia marcescens heptosyltransferase II WaaF SWALL:Q936B7 (EMBL:U52844) (348 aa) fasta scores: E(): 7e-115, 79.36% id in 344 aa.
   
 0.936
hisI
Similar to Escherichia coli histidine biosynthesis bifunctional protein HisIE [includes: phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphatase HisI or hisie or b2026 SWALL:HIS2_ECOLI (SWALL:P06989) (203 aa) fasta scores: E(): 2e-64, 80.09% id in 201 aa; In the N-terminal section; belongs to the PRA-CH family.
  
  
 0.902
waaQ
Similar to Escherichia coli lipopolysaccharide core biosynthesis glycosyl transferase RfaQ or WaaQ or b3632 SWALL:RFAQ_ECOLI (SWALL:P25742) (344 aa) fasta scores: E(): 1.3e-65, 52.69% id in 334 aa, and to Salmonella typhimurium lipopolysaccharide core biosynthesis, modification of heptose region of core RfaQ or stm3723 SWALL:O68270 (EMBL:AF026386) (344 aa) fasta scores: E(): 1.2e-64, 51.79% id in 334 aa.
 
   
 0.764
rfaD
ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
 
  
 0.674
waaC
Similar to Escherichia coli lipopolysaccharide heptosyltransferase-1 RfaC or WaaC or Rfa-2 or b3621 SWALL:RFAC_ECOLI (SWALL:P24173) (319 aa) fasta scores: E(): 6.6e-89, 71.47% id in 319 aa, and to Serratia marcescens heptosyltransferase i WaaC SWALL:Q936B6 (EMBL:U52844) (321 aa) fasta scores: E(): 8.9e-98, 76.25% id in 320 aa.
 
   
 0.635
hisF
Imidazole glycerol phosphate synthase subunit hisf; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.635
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
  
 0.634
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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