STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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[Homology]
Score
queEConserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (223 aa)    
Predicted Functional Partners:
queC
Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)); Belongs to the QueC family.
 
 
 0.999
ECA3553
Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri putative 6-pyruvoyl tetrahydrobiopterin synthase YgcM or b2765 or z4075 or ecs3620 or sf2781 SWALL:PTPS_ECOLI (SWALL:Q46903) (121 aa) fasta scores: E(): 8.1e-44, 86.66% id in 120 aa.
 
 
 0.997
queF
Putative GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
  
  
 0.856
folE
GTP cyclohydrolase I; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri GTP cyclohydrolase I FolE or b2153 or c2688 or z3409 or ecs3045 or sf2238 SWALL:GCH1_ECOLI (SWALL:P27511) (221 aa) fasta scores: E(): 9.1e-71, 88.18% id in 220 aa.
  
  
 0.827
nrdD
Similar to Escherichia coli anaerobic ribonucleoside-triphosphate reductase NrdD or b4238 SWALL:NRDD_ECOLI (SWALL:P28903) (712 aa) fasta scores: E(): 0, 85.97% id in 713 aa.
  
 
 0.740
ECA2748
Similar to Yersinia pestis hypothetical protein Ypo1261 SWALL:Q8ZGM6 (EMBL:AJ414147) (75 aa) fasta scores: E(): 4.5e-22, 85.52% id in 76 aa, and to Salmonella typhimurium, and Salmonella typhi putative cytoplasmic protein yejl or stm2227 or sty2465 SWALL:Q8XEL6 (EMBL:AE008799) (75 aa) fasta scores: E(): 1.6e-19, 78.94% id in 76 aa; Belongs to the UPF0352 family.
  
     0.641
ECA4055
Putative exported protein; Similar to Yersinia pestis hypothetical protein ypo0192 or y3973 SWALL:Q8ZJC3 (EMBL:AJ414141) (73 aa) fasta scores: E(): 1.2e-12, 60% id in 65 aa, and to Shigella flexneri orf, conserved hypothetical protein yhev or sf3368 SWALL:AAN44831 (EMBL:AE015345) (66 aa) fasta scores: E(): 4.4e-11, 50% id in 64 aa.
  
     0.639
nadA
Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily.
 
   
 0.586
ruvC
Crossover junction endodeoxyribonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
     
 0.566
seqA
Putative negative regulator of replication initiation; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
  
     0.560
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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