Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ECA3582Similar to Yersinia pestis hypothetical protein Ypo2988 SWALL:Q8ZCJ7 (EMBL:AJ414154) (71 aa) fasta scores: E(): 8.4e-21, 79.7% id in 69 aa, and to Escherichia coli, and Escherichia coli O157:H7 hypothetical protein ypeb or b2410.1 or z3676 or ecs3282.1 SWALL:YPEB_ECOLI (SWALL:P56604) (72 aa) fasta scores: E(): 8.5e-21, 80.28% id in 71 aa. (73 aa)    
Predicted Functional Partners:
ligA
DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
       0.577
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
     0.503
acpH
Conserved hypothetical protein; Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; Belongs to the AcpH family.
  
     0.446
ECA2239
Similar to Erwinia pyrifoliae conserved hypothetical protein SWALL:AAN04552 (EMBL:AY123045) (94 aa) fasta scores: E(): 2.6e-22, 66.31% id in 95 aa, and to Yersinia pestis hypothetical protein ypo1157 or y3025 SWALL:Q8ZGW6 (EMBL:AJ414146) (81 aa) fasta scores: E(): 2.7e-16, 63.51% id in 74 aa.
  
     0.440
rfaE
ADP-heptose synthase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family.
       0.433
cusB
Similar to Escherichia coli putative copper efflux system protein CusB precursor CusB or b0574 SWALL:CUSB_ECOLI (SWALL:P77239) (407 aa) fasta scores: E(): 8.2e-44, 37.94% id in 398 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
    0.404
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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