node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ECA3005 | ECA3631 | ECA3005 | ECA3631 | Similar to Ralstonia solanacearum putative glutamine amidotransferase protein rsc0213 or rs00645 SWALL:Q8Y2W9 (EMBL:AL646058) (238 aa) fasta scores: E(): 9e-37, 45.37% id in 238 aa, and to Xylella fastidiosa GMP synthase xf0560 SWALL:Q9PFU7 (EMBL:AE003903) (240 aa) fasta scores: E(): 1.1e-28, 43.8% id in 242 aa. | Ham1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.910 |
ECA3005 | gpt | ECA3005 | ECA3466 | Similar to Ralstonia solanacearum putative glutamine amidotransferase protein rsc0213 or rs00645 SWALL:Q8Y2W9 (EMBL:AL646058) (238 aa) fasta scores: E(): 9e-37, 45.37% id in 238 aa, and to Xylella fastidiosa GMP synthase xf0560 SWALL:Q9PFU7 (EMBL:AE003903) (240 aa) fasta scores: E(): 1.1e-28, 43.8% id in 242 aa. | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.929 |
ECA3005 | guaA | ECA3005 | ECA3208 | Similar to Ralstonia solanacearum putative glutamine amidotransferase protein rsc0213 or rs00645 SWALL:Q8Y2W9 (EMBL:AL646058) (238 aa) fasta scores: E(): 9e-37, 45.37% id in 238 aa, and to Xylella fastidiosa GMP synthase xf0560 SWALL:Q9PFU7 (EMBL:AE003903) (240 aa) fasta scores: E(): 1.1e-28, 43.8% id in 242 aa. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.924 |
ECA3005 | guaB | ECA3005 | ECA3209 | Similar to Ralstonia solanacearum putative glutamine amidotransferase protein rsc0213 or rs00645 SWALL:Q8Y2W9 (EMBL:AL646058) (238 aa) fasta scores: E(): 9e-37, 45.37% id in 238 aa, and to Xylella fastidiosa GMP synthase xf0560 SWALL:Q9PFU7 (EMBL:AE003903) (240 aa) fasta scores: E(): 1.1e-28, 43.8% id in 242 aa. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.958 |
ECA3005 | hpt | ECA3005 | ECA3328 | Similar to Ralstonia solanacearum putative glutamine amidotransferase protein rsc0213 or rs00645 SWALL:Q8Y2W9 (EMBL:AL646058) (238 aa) fasta scores: E(): 9e-37, 45.37% id in 238 aa, and to Xylella fastidiosa GMP synthase xf0560 SWALL:Q9PFU7 (EMBL:AE003903) (240 aa) fasta scores: E(): 1.1e-28, 43.8% id in 242 aa. | Similar to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt or stm0170 SWALL:HPRT_SALTY (SWALL:O33799) (178 aa) fasta scores: E(): 1.2e-54, 86.2% id in 174 aa, and to Escherichia coli, Escherichia coli O6, and Shigella flexneri hypoxanthine phosphoribosyltransferase Hpt or b0125 or c0154 or sf0122 SWALL:HPRT_ECOLI (SWALL:P36766) (178 aa) fasta scores: E(): 2.4e-54, 84.48% id in 174 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.924 |
ECA3005 | ushA | ECA3005 | ECA1184 | Similar to Ralstonia solanacearum putative glutamine amidotransferase protein rsc0213 or rs00645 SWALL:Q8Y2W9 (EMBL:AL646058) (238 aa) fasta scores: E(): 9e-37, 45.37% id in 238 aa, and to Xylella fastidiosa GMP synthase xf0560 SWALL:Q9PFU7 (EMBL:AE003903) (240 aa) fasta scores: E(): 1.1e-28, 43.8% id in 242 aa. | Similar to Escherichia coli protein UshA precursor [includes: UDP-sugar hydrolase and 5'-nucleotidase] UshA or b0480 SWALL:USHA_ECOLI (SWALL:P07024) (550 aa) fasta scores: E(): 1.6e-157, 71.5% id in 551 aa; Belongs to the 5'-nucleotidase family. | 0.906 |
ECA3631 | ECA3005 | ECA3631 | ECA3005 | Ham1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Similar to Ralstonia solanacearum putative glutamine amidotransferase protein rsc0213 or rs00645 SWALL:Q8Y2W9 (EMBL:AL646058) (238 aa) fasta scores: E(): 9e-37, 45.37% id in 238 aa, and to Xylella fastidiosa GMP synthase xf0560 SWALL:Q9PFU7 (EMBL:AE003903) (240 aa) fasta scores: E(): 1.1e-28, 43.8% id in 242 aa. | 0.910 |
ECA3631 | ECA3632 | ECA3631 | ECA3632 | Ham1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.910 |
ECA3631 | gpt | ECA3631 | ECA3466 | Ham1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.917 |
ECA3631 | guaA | ECA3631 | ECA3208 | Ham1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.972 |
ECA3631 | guaB | ECA3631 | ECA3209 | Ham1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.935 |
ECA3631 | hpt | ECA3631 | ECA3328 | Ham1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Similar to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt or stm0170 SWALL:HPRT_SALTY (SWALL:O33799) (178 aa) fasta scores: E(): 1.2e-54, 86.2% id in 174 aa, and to Escherichia coli, Escherichia coli O6, and Shigella flexneri hypoxanthine phosphoribosyltransferase Hpt or b0125 or c0154 or sf0122 SWALL:HPRT_ECOLI (SWALL:P36766) (178 aa) fasta scores: E(): 2.4e-54, 84.48% id in 174 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.909 |
ECA3631 | murI | ECA3631 | ECA4237 | Ham1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.905 |
ECA3631 | ndk | ECA3631 | ECA3224 | Ham1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.934 |
ECA3631 | rph | ECA3631 | ECA0140 | Ham1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.960 |
ECA3631 | ushA | ECA3631 | ECA1184 | Ham1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Similar to Escherichia coli protein UshA precursor [includes: UDP-sugar hydrolase and 5'-nucleotidase] UshA or b0480 SWALL:USHA_ECOLI (SWALL:P07024) (550 aa) fasta scores: E(): 1.6e-157, 71.5% id in 551 aa; Belongs to the 5'-nucleotidase family. | 0.900 |
ECA3632 | ECA3631 | ECA3632 | ECA3631 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Ham1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.910 |
gpt | ECA3005 | ECA3466 | ECA3005 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | Similar to Ralstonia solanacearum putative glutamine amidotransferase protein rsc0213 or rs00645 SWALL:Q8Y2W9 (EMBL:AL646058) (238 aa) fasta scores: E(): 9e-37, 45.37% id in 238 aa, and to Xylella fastidiosa GMP synthase xf0560 SWALL:Q9PFU7 (EMBL:AE003903) (240 aa) fasta scores: E(): 1.1e-28, 43.8% id in 242 aa. | 0.929 |
gpt | ECA3631 | ECA3466 | ECA3631 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | Ham1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.917 |
gpt | guaA | ECA3466 | ECA3208 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.989 |