STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (468 aa)    
Predicted Functional Partners:
dnaA
Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
 
 
 0.947
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
 
 0.928
dnaE
Similar to Escherichia coli DNA polymerase III alpha subunit DnaE or PolC or b0184 SWALL:DP3A_ECOLI (SWALL:P10443) (1160 aa) fasta scores: E(): 0, 88.1% id in 1160 aa.
 
 
 0.863
dnaX
DNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 
 0.793
rpoA
DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
  
 0.764
alr
Alanine racemase, biosynthetic; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.
 
   
 0.720
hda
Conserved hypothetical protein; Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity); Belongs to the DnaA family. HdA subfamily.
   
 
 0.713
ECA3808
Similar to Yersinia pestis hypothetical protein ypo0562 or y3619 SWALL:Q8ZIE2 (EMBL:AJ414143) (176 aa) fasta scores: E(): 4.8e-42, 67.81% id in 174 aa, and to Vibrio cholerae hypothetical protein Vc2395 SWALL:Q9KPH3 (EMBL:AE004310) (157 aa) fasta scores: E(): 3.3e-11, 33.74% id in 163 aa.
    
   0.691
ECA3390
DnaG primase-like protein; Similar to Photorhabdus luminescens DnaG primase-like dnaG SWALL:AAN64202 (EMBL:AY144117) (925 aa) fasta scores: E(): 2.5e-133, 71.76% id in 928 aa, and to the N-terminal region of Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri DNA primase dnag or dnap or parb or b3066 or z4419 or ecs3949 or sf3107 SWALL:PRIM_ECOLI (SWALL:P02923) (581 aa) fasta scores: E(): 2.7e-13, 29.1% id in 378 aa. Also similar to ECA3400, (82.939% id), ECA3407 (85.082% id), ECA3416 (85.082% id), ECA4282 (80.041% id), and to ECA4291 (80.041% id).
  
 0.687
ECA3400
DnaG primase-like protein; Similar to Photorhabdus luminescens DnaG primase-like DnaG SWALL:AAN64202 (EMBL:AY144117) (925 aa) fasta scores: E(): 5.1e-145, 74.15% id in 921 aa, and to the C-terminal region of Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri DNA primase DnaG or DnaP or ParB or b3066 or z4419 or ecs3949 or sf3107 SWALL:PRIM_ECOLI (SWALL:P02923) (581 aa) fasta scores: E(): 9.7e-14, 29.11% id in 395 aa. Also similar to ECA3390, (82.939% id), ECA3407 (86.812% id), ECA3416 (86.812% id), ECA4282 (84.394% id), and to ECA4291 (84.394% id).
  
 0.687
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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