STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvHSimilar to Escherichia coli acetolactate synthase isozyme III small subunit IlvH or BrnP or b0078 SWALL:ILVH_ECOLI (SWALL:P00894) (163 aa) fasta scores: E(): 1.2e-48, 87.11% id in 163 aa. (163 aa)    
Predicted Functional Partners:
ilvI
Similar to Escherichia coli acetolactate synthase isozyme III large subunit IlvI or b0077 SWALL:ILVI_ECOLI (SWALL:P00893) (574 aa) fasta scores: E(): 1e-187, 83.27% id in 574 aa.
 
 0.998
ECA1426
Putative thiamine pyrophosphate enzyme; Similar to Bacillus subtilis acetolactate synthase large subunit IlvB SWALL:ILVB_BACSU (SWALL:P37251) (573 aa) fasta scores: E(): 5.9e-45, 32.32% id in 563 aa; Belongs to the TPP enzyme family.
 
 0.991
ilvB
Similar to Escherichia coli acetolactate synthase isozyme I large subunit IlvB or b3671 SWALL:ILVB_ECOLI (SWALL:P08142) (562 aa) fasta scores: E(): 3.2e-154, 71.24% id in 553 aa.
 
 0.991
ilvG
Similar to Escherichia coli acetolactate synthase isozyme II large subunit IlvG or b3767 SWALL:ILVG_ECOLI (SWALL:P00892) (548 aa) fasta scores: E(): 9.5e-169, 80.22% id in 546 aa.
 
 0.991
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
 
 0.986
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.980
budB
Similar to Klebsiella pneumoniae acetolactate synthase, catabolic budb or ilvK SWALL:ILVB_KLEPN (SWALL:P27696) (559 aa) fasta scores: E(): 6.5e-143, 66% id in 556 aa, and to Klebsiella terrigena acetolactate synthase, catabolic budB SWALL:ILVB_KLETE (SWALL:Q04524) (559 aa) fasta scores: E(): 4.5e-137, 64.15% id in 558 aa; Belongs to the TPP enzyme family.
 
 0.979
ilvA
Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
 
 
 0.957
tdcB
Putative threonine dehydratase catabolic; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri threonine dehydratase catabolic TdcB or b3117 or c3875 or z4469 or ecs3997 or sf3157 SWALL:THD2_ECOLI (SWALL:P05792) (329 aa) fasta scores: E(): 9.6e-33, 38.14% id in 312 aa, and to Thermotoga maritima threonine dehydratase catabolic tm0356 SWALL:Q9WYJ1 (EMBL:AE001716) (401 aa) fasta scores: E(): 6.1e-41, 41.32% id in 317 aa.
  
 
 0.950
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.940
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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