STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvISimilar to Escherichia coli acetolactate synthase isozyme III large subunit IlvI or b0077 SWALL:ILVI_ECOLI (SWALL:P00893) (574 aa) fasta scores: E(): 1e-187, 83.27% id in 574 aa. (572 aa)    
Predicted Functional Partners:
ilvH
Similar to Escherichia coli acetolactate synthase isozyme III small subunit IlvH or BrnP or b0078 SWALL:ILVH_ECOLI (SWALL:P00894) (163 aa) fasta scores: E(): 1.2e-48, 87.11% id in 163 aa.
 
 0.998
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
 
 0.981
ilvN
Acetolactate synthase isozyme I small subunit; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 acetolactate synthase isozyme I small subunit IlvN or b3670 or c4595 or z5164 or ecs4611 SWALL:ILVN_ECOLI (SWALL:P08143) (96 aa) fasta scores: E(): 1.9e-22, 62.5% id in 96 aa.
 
 0.975
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.974
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.954
budA
Similar to Enterobacter aerogenes alpha-acetolactate decarboxylase aldC SWALL:ALDC_ENTAE (SWALL:P05361) (260 aa) fasta scores: E(): 6.2e-63, 59.76% id in 251 aa, and to Klebsiella terrigena alpha-acetolactate decarboxylase budA SWALL:ALDC_KLETE (SWALL:Q04518) (259 aa) fasta scores: E(): 1.1e-62, 58.26% id in 254 aa.
  
 
 0.950
ECA0824
Similar to Rhodospirillum rubrum pyruvate-flavodoxin oxidoreductase NifJ SWALL:NIFJ_RHORU (SWALL:Q53046) (1191 aa) fasta scores: E(): 0, 54.73% id in 1182 aa, and to Escherichia coli probable pyruvate-flavodoxin oxidoreductase ydbk or b1378 SWALL:NIFJ_ECOLI (SWALL:P52647) (1174 aa) fasta scores: E(): 0, 78.79% id in 1174 aa. Also similar to ECA2957 (47.377% id. in 1182 aa overlap).
  
 
 0.948
ilvA
Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
 
 0.931
ilvM
Acetolactate synthase isozyme II small subunit; Similar to Escherichia coli, Escherichia coli O6, and Shigella flexneri acetolactate synthase isozyme II small subunit IlvM or b3769 or c4691 or sf3844 SWALL:ILVM_ECOLI (SWALL:P13048) (86 aa) fasta scores: E(): 1.8e-18, 63.52% id in 85 aa.
  
 0.926
ECA1426
Putative thiamine pyrophosphate enzyme; Similar to Bacillus subtilis acetolactate synthase large subunit IlvB SWALL:ILVB_BACSU (SWALL:P37251) (573 aa) fasta scores: E(): 5.9e-45, 32.32% id in 563 aa; Belongs to the TPP enzyme family.
  
  
 
0.924
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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