STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (383 aa)    
Predicted Functional Partners:
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 0.979
metE-2
5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Similar to Pseudomonas putida MetE SWALL:Q9AF89 (EMBL:AF363277) (361 aa) fasta scores: E(): 1.6e-114, 82.94% id in 340 aa, and to Agrobacterium tumefaciens 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase MetE or atu3823 or agr_l_2018 SWALL:Q8U9A5 (EMBL:AE009313) (342 aa) fasta scores: E(): 3.4e-124, 90.29% id in 340 aa.
  
 0.978
ECA1113
Putative methionine synthase; Similar to Bradyrhizobium japonicum Bll5948 protein bll5948 SWALL:BAC51213 (EMBL:AP005956) (372 aa) fasta scores: E(): 7.6e-92, 59.45% id in 370 aa, and to Listeria innocua hypothetical protein Lin0838 lin0838 SWALL:Q92DH5 (EMBL:AL596166) (367 aa) fasta scores: E(): 1.8e-84, 55.97% id in 368 aa.
  
 0.961
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.948
speD
S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
    
 0.936
mmuM
Similar to Escherichia coli homocysteine S-methyltransferase MmuM or b0261 SWALL:MMUM_ECOLI (SWALL:Q47690) (310 aa) fasta scores: E(): 2e-82, 68.85% id in 305 aa.
     
 0.930
tyrB
Similar to Escherichia coli aromatic-amino-acid aminotransferase tyrb or b4054 SWALL:TYRB_ECOLI (SWALL:P04693) (397 aa) fasta scores: E(): 1.9e-115, 74.24% id in 396 aa.
     
 0.907
ECA2461
Similar to Yersinia pestis hypothetical protein Ypo1703 SWALL:Q8ZFK0 (EMBL:AJ414150) (165 aa) fasta scores: E(): 6.2e-43, 66.25% id in 160 aa, and to Shigella flexneri orf, conserved hypothetical protein yebr or sf1393 SWALL:AAN42994 (EMBL:AE015164) (165 aa) fasta scores: E(): 1.6e-41, 63.8% id in 163 aa.
     
  0.900
metF
Similar to Erwinia carotovora 5,10-methylenetetrahydrofolate reductase MetF SWALL:METF_ERWCA (SWALL:P71319) (298 aa) fasta scores: E(): 4.2e-114, 97.65% id in 298 aa, and to Escherichia coli, and Shigella flexneri 5,10-methylenetetrahydrofolate reductase MetF or b3941 or sf4019 SWALL:METF_ECOLI (SWALL:P00394) (296 aa) fasta scores: E(): 2.1e-101, 86.05% id in 294 aa.
  
  
 0.860
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family.
  
 
 0.849
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.