| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ECA4197 | guaB | ECA4197 | ECA3209 | Probable lyase; Similar to Bacillus subtilis adenylosuccinate lyase PurB or PurE SWALL:PUR8_BACSU (SWALL:P12047) (431 aa) fasta scores: E(): 1.2e-45, 34.97% id in 406 aa, and to Pseudomonas aeruginosa probable lyase pa3517 SWALL:Q9HY92 (EMBL:AE004772) (477 aa) fasta scores: E(): 7.9e-71, 43.94% id in 446 aa. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.548 |
| ECA4197 | guaC | ECA4197 | ECA3801 | Probable lyase; Similar to Bacillus subtilis adenylosuccinate lyase PurB or PurE SWALL:PUR8_BACSU (SWALL:P12047) (431 aa) fasta scores: E(): 1.2e-45, 34.97% id in 406 aa, and to Pseudomonas aeruginosa probable lyase pa3517 SWALL:Q9HY92 (EMBL:AE004772) (477 aa) fasta scores: E(): 7.9e-71, 43.94% id in 446 aa. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.548 |
| ECA4197 | purA | ECA4197 | ECA3929 | Probable lyase; Similar to Bacillus subtilis adenylosuccinate lyase PurB or PurE SWALL:PUR8_BACSU (SWALL:P12047) (431 aa) fasta scores: E(): 1.2e-45, 34.97% id in 406 aa, and to Pseudomonas aeruginosa probable lyase pa3517 SWALL:Q9HY92 (EMBL:AE004772) (477 aa) fasta scores: E(): 7.9e-71, 43.94% id in 446 aa. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.995 |
| ECA4197 | purB | ECA4197 | ECA2444 | Probable lyase; Similar to Bacillus subtilis adenylosuccinate lyase PurB or PurE SWALL:PUR8_BACSU (SWALL:P12047) (431 aa) fasta scores: E(): 1.2e-45, 34.97% id in 406 aa, and to Pseudomonas aeruginosa probable lyase pa3517 SWALL:Q9HY92 (EMBL:AE004772) (477 aa) fasta scores: E(): 7.9e-71, 43.94% id in 446 aa. | Adenylosuccinate lyase; Similar to Escherichia coli, and Escherichia coli O6 adenylosuccinate lyase PurB or b1131 or c1510 SWALL:PUR8_ECOLI (SWALL:P25739) (456 aa) fasta scores: E(): 1.8e-159, 88.81% id in 456 aa. | 0.944 |
| ECA4197 | purC | ECA4197 | ECA1264 | Probable lyase; Similar to Bacillus subtilis adenylosuccinate lyase PurB or PurE SWALL:PUR8_BACSU (SWALL:P12047) (431 aa) fasta scores: E(): 1.2e-45, 34.97% id in 406 aa, and to Pseudomonas aeruginosa probable lyase pa3517 SWALL:Q9HY92 (EMBL:AE004772) (477 aa) fasta scores: E(): 7.9e-71, 43.94% id in 446 aa. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri phosphoribosylaminoimidazole-succinocarboxamide synthase PurC or b2476 or c3004 or z3735 or ecs3338 or sf2519 SWALL:PUR7_ECOLI (SWALL:P21155) (237 aa) fasta scores: E(): 1.1e-84, 90.71% id in 237 aa; Belongs to the SAICAR synthetase family. | 0.998 |
| ECA4197 | purE | ECA4197 | ECA3156 | Probable lyase; Similar to Bacillus subtilis adenylosuccinate lyase PurB or PurE SWALL:PUR8_BACSU (SWALL:P12047) (431 aa) fasta scores: E(): 1.2e-45, 34.97% id in 406 aa, and to Pseudomonas aeruginosa probable lyase pa3517 SWALL:Q9HY92 (EMBL:AE004772) (477 aa) fasta scores: E(): 7.9e-71, 43.94% id in 446 aa. | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.911 |
| ECA4197 | purH | ECA4197 | ECA0241 | Probable lyase; Similar to Bacillus subtilis adenylosuccinate lyase PurB or PurE SWALL:PUR8_BACSU (SWALL:P12047) (431 aa) fasta scores: E(): 1.2e-45, 34.97% id in 406 aa, and to Pseudomonas aeruginosa probable lyase pa3517 SWALL:Q9HY92 (EMBL:AE004772) (477 aa) fasta scores: E(): 7.9e-71, 43.94% id in 446 aa. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Similar to Escherichia coli bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase] PurH or b4006 SWALL:PUR9_ECOLI (SWALL:P15639) (529 aa) fasta scores: E(): 3.7e-184, 88.84% id in 529 aa. | 0.990 |
| ECA4197 | purK | ECA4197 | ECA3157 | Probable lyase; Similar to Bacillus subtilis adenylosuccinate lyase PurB or PurE SWALL:PUR8_BACSU (SWALL:P12047) (431 aa) fasta scores: E(): 1.2e-45, 34.97% id in 406 aa, and to Pseudomonas aeruginosa probable lyase pa3517 SWALL:Q9HY92 (EMBL:AE004772) (477 aa) fasta scores: E(): 7.9e-71, 43.94% id in 446 aa. | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.893 |
| ECA4197 | purN | ECA4197 | ECA1253 | Probable lyase; Similar to Bacillus subtilis adenylosuccinate lyase PurB or PurE SWALL:PUR8_BACSU (SWALL:P12047) (431 aa) fasta scores: E(): 1.2e-45, 34.97% id in 406 aa, and to Pseudomonas aeruginosa probable lyase pa3517 SWALL:Q9HY92 (EMBL:AE004772) (477 aa) fasta scores: E(): 7.9e-71, 43.94% id in 446 aa. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.718 |
| guaB | ECA4197 | ECA3209 | ECA4197 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Probable lyase; Similar to Bacillus subtilis adenylosuccinate lyase PurB or PurE SWALL:PUR8_BACSU (SWALL:P12047) (431 aa) fasta scores: E(): 1.2e-45, 34.97% id in 406 aa, and to Pseudomonas aeruginosa probable lyase pa3517 SWALL:Q9HY92 (EMBL:AE004772) (477 aa) fasta scores: E(): 7.9e-71, 43.94% id in 446 aa. | 0.548 |
| guaB | guaC | ECA3209 | ECA3801 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.955 |
| guaB | purA | ECA3209 | ECA3929 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.987 |
| guaB | purB | ECA3209 | ECA2444 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate lyase; Similar to Escherichia coli, and Escherichia coli O6 adenylosuccinate lyase PurB or b1131 or c1510 SWALL:PUR8_ECOLI (SWALL:P25739) (456 aa) fasta scores: E(): 1.8e-159, 88.81% id in 456 aa. | 0.591 |
| guaB | purC | ECA3209 | ECA1264 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri phosphoribosylaminoimidazole-succinocarboxamide synthase PurC or b2476 or c3004 or z3735 or ecs3338 or sf2519 SWALL:PUR7_ECOLI (SWALL:P21155) (237 aa) fasta scores: E(): 1.1e-84, 90.71% id in 237 aa; Belongs to the SAICAR synthetase family. | 0.548 |
| guaB | purE | ECA3209 | ECA3156 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.639 |
| guaB | purH | ECA3209 | ECA0241 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Similar to Escherichia coli bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase] PurH or b4006 SWALL:PUR9_ECOLI (SWALL:P15639) (529 aa) fasta scores: E(): 3.7e-184, 88.84% id in 529 aa. | 0.993 |
| guaB | purK | ECA3209 | ECA3157 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.877 |
| guaB | purN | ECA3209 | ECA1253 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.459 |
| guaC | ECA4197 | ECA3801 | ECA4197 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Probable lyase; Similar to Bacillus subtilis adenylosuccinate lyase PurB or PurE SWALL:PUR8_BACSU (SWALL:P12047) (431 aa) fasta scores: E(): 1.2e-45, 34.97% id in 406 aa, and to Pseudomonas aeruginosa probable lyase pa3517 SWALL:Q9HY92 (EMBL:AE004772) (477 aa) fasta scores: E(): 7.9e-71, 43.94% id in 446 aa. | 0.548 |
| guaC | guaB | ECA3801 | ECA3209 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.955 |
