STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ahpCAlkyl hydroperoxide reductase C22 protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (187 aa)    
Predicted Functional Partners:
ahpF
Similar to Escherichia coli alkyl hydroperoxide reductase subunit F AhpF or b0606 SWALL:AHPF_ECOLI (SWALL:P35340) (521 aa) fasta scores: E(): 3.1e-149, 78.09% id in 525 aa; EC number 1.6.4.-.
 
  
 0.982
ECA2649
Thioredoxin reductase.
  
 
 0.892
ECA1516
Similar to Yersinia pestis putative thioredoxin-family protein y2363 SWALL:AAM85921 (EMBL:AE013839) (176 aa) fasta scores: E(): 3.3e-34, 60.49% id in 162 aa, and to Pasteurella multocida ResA or pm0447 SWALL:Q9CNI4 (EMBL:AE006080) (175 aa) fasta scores: E(): 3e-18, 40% id in 165 aa.
  
 0.784
dsbE
Thiol:disulfide interchange protein; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri thiol:disulfide interchange protein DsbE or CcmG or b2195 or z3452 or ecs3084 or sf2279 SWALL:DSBE_ECOLI (SWALL:P33926) (185 aa) fasta scores: E(): 5.4e-57, 77.47% id in 182 aa.
  
 0.784
sodA
Manganese superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
  
  
 0.742
hmpX
Flavohemoprotein; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily.
      
 0.653
fur
Ferric uptake regulation protein; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 ferric uptake regulation protein Fur or b0683 or c0770 or z0831 or ecs0714 SWALL:FUR_ECOLI (SWALL:P06975) (148 aa) fasta scores: E(): 9.2e-52, 91.09% id in 146 aa; Belongs to the Fur family.
  
  
 0.644
dps
DNA protection during starvation protein; During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.
  
  
 0.636
norV
Anaerobic nitric oxide reductase flavorubredoxin; Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase; In the N-terminal section; belongs to the zinc metallo- hydrolase group 3 family.
  
  
 0.620
ECA3943
Putative membrane protein; Similar to Xanthomonas campestris hypothetical protein Xcc2749 SWALL:Q8P764 (EMBL:AE012388) (618 aa) fasta scores: E(): 1.9e-27, 29.05% id in 592 aa, and to Caulobacter crescentus hypothetical protein Cc3419 SWALL:Q9A2Y7 (EMBL:AE006002) (582 aa) fasta scores: E(): 2.8e-27, 28.7% id in 554 aa.
  
 
 0.579
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.