STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metH5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1227 aa)    
Predicted Functional Partners:
metF
Similar to Erwinia carotovora 5,10-methylenetetrahydrofolate reductase MetF SWALL:METF_ERWCA (SWALL:P71319) (298 aa) fasta scores: E(): 4.2e-114, 97.65% id in 298 aa, and to Escherichia coli, and Shigella flexneri 5,10-methylenetetrahydrofolate reductase MetF or b3941 or sf4019 SWALL:METF_ECOLI (SWALL:P00394) (296 aa) fasta scores: E(): 2.1e-101, 86.05% id in 294 aa.
 
 
 0.998
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.984
ECA1113
Putative methionine synthase; Similar to Bradyrhizobium japonicum Bll5948 protein bll5948 SWALL:BAC51213 (EMBL:AP005956) (372 aa) fasta scores: E(): 7.6e-92, 59.45% id in 370 aa, and to Listeria innocua hypothetical protein Lin0838 lin0838 SWALL:Q92DH5 (EMBL:AL596166) (367 aa) fasta scores: E(): 1.8e-84, 55.97% id in 368 aa.
  
 
 0.984
metE-2
5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Similar to Pseudomonas putida MetE SWALL:Q9AF89 (EMBL:AF363277) (361 aa) fasta scores: E(): 1.6e-114, 82.94% id in 340 aa, and to Agrobacterium tumefaciens 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase MetE or atu3823 or agr_l_2018 SWALL:Q8U9A5 (EMBL:AE009313) (342 aa) fasta scores: E(): 3.4e-124, 90.29% id in 340 aa.
  
 
 0.984
metC
Similar to Escherichia coli cystathionine beta-lyase MetC or b3008 SWALL:METC_ECOLI (SWALL:P06721) (395 aa) fasta scores: E(): 8.3e-124, 73.85% id in 394 aa.
  
 
 0.975
metB
Similar to Escherichia coli cystathionine gamma-synthase MetB or b3939 SWALL:METB_ECOLI (SWALL:P00935) (386 aa) fasta scores: E(): 3.8e-129, 87.01% id in 385 aa.
  
 
 0.975
thrA
Similar to Escherichia coli bifunctional aspartokinase/homoserine dehydrogenase I [includes: aspartokinase I; homoserine dehydrogenase I] thra or thra1 or thra2 or b0002 SWALL:AK1H_ECOLI (SWALL:P00561) (820 aa) fasta scores: E(): 0, 82.41% id in 819 aa; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.962
metL
Similar to Escherichia coli bifunctional aspartokinase/homoserine dehydrogenase II MetL or MetM or b3940 SWALL:AK2H_ECOLI (SWALL:P00562) (809 aa) fasta scores: E(): 0, 83.12% id in 800 aa; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.962
gcvT
Glycine cleavage system T protein (aminomethyltransferase); The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.954
ECA0820
Similar to Emericella nidulans O-acetyl-L-homoserine sulfhydrylase CysD SWALL:O13387 (EMBL:AF029318) (437 aa) fasta scores: E(): 2.6e-79, 52.47% id in 425 aa, and to Shewanella oneidensis O-acetylhomoserine so1095 SWALL:AAN54166 (EMBL:AE015554) (430 aa) fasta scores: E(): 3.2e-138, 85.21% id in 426 aa.
  
 
 0.949
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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