Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
aceAIsocitrate lyase; Similar to Escherichia coli, and Escherichia coli O6 isocitrate lyase AceA or Icl or b4015 or c4972 SWALL:ACEA_ECOLI (SWALL:P05313) (434 aa) fasta scores: E(): 4.7e-157, 86.8% id in 432 aa. (435 aa)    
Predicted Functional Partners:
aceB
Similar to Escherichia coli malate synthase A AceB or Mas or b4014 SWALL:MASY_ECOLI (SWALL:P08997) (533 aa) fasta scores: E(): 6.4e-180, 82.04% id in 529 aa.
 
 0.999
pta
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
   
 
 0.988
acnB
Aconitate hydratase 2; Similar to Escherichia coli aconitate hydratase 2 AcnB or b0118 SWALL:ACO2_ECOLI (SWALL:P36683) (865 aa) fasta scores: E(): 0, 91.32% id in 865 aa; Belongs to the aconitase/IPM isomerase family.
   
 
 0.978
aceK
Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
 
  
 0.963
ECA0824
Similar to Rhodospirillum rubrum pyruvate-flavodoxin oxidoreductase NifJ SWALL:NIFJ_RHORU (SWALL:Q53046) (1191 aa) fasta scores: E(): 0, 54.73% id in 1182 aa, and to Escherichia coli probable pyruvate-flavodoxin oxidoreductase ydbk or b1378 SWALL:NIFJ_ECOLI (SWALL:P52647) (1174 aa) fasta scores: E(): 0, 78.79% id in 1174 aa. Also similar to ECA2957 (47.377% id. in 1182 aa overlap).
    
 0.962
sucC
succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
   
 
 0.959
sucD
succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
   
 
 0.954
frdA
Similar to Escherichia coli fumarate reductase flavoprotein subunit FrdA or b4154 SWALL:FRDA_ECOLI (SWALL:P00363) (601 aa) fasta scores: E(): 4.9e-203, 84.52% id in 601 aa.
   
 
 0.953
aceF
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
   
 
 0.950
frdB
Fumarate reductase iron-sulfur protein; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri fumarate reductase iron-sulfur protein frdB or b4153 or c5241 or z5760 or ecs5134 or sf4311 SWALL:FRDB_ECOLI (SWALL:P00364) (243 aa) fasta scores: E(): 2.8e-84, 85.24% id in 244 aa; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
   
 
 0.949
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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