| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ECA0820 | ilvA | ECA0820 | ECA4225 | Similar to Emericella nidulans O-acetyl-L-homoserine sulfhydrylase CysD SWALL:O13387 (EMBL:AF029318) (437 aa) fasta scores: E(): 2.6e-79, 52.47% id in 425 aa, and to Shewanella oneidensis O-acetylhomoserine so1095 SWALL:AAN54166 (EMBL:AE015554) (430 aa) fasta scores: E(): 3.2e-138, 85.21% id in 426 aa. | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.945 |
| ECA0820 | metA | ECA0820 | ECA3992 | Similar to Emericella nidulans O-acetyl-L-homoserine sulfhydrylase CysD SWALL:O13387 (EMBL:AF029318) (437 aa) fasta scores: E(): 2.6e-79, 52.47% id in 425 aa, and to Shewanella oneidensis O-acetylhomoserine so1095 SWALL:AAN54166 (EMBL:AE015554) (430 aa) fasta scores: E(): 3.2e-138, 85.21% id in 426 aa. | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.991 |
| ECA0820 | metB | ECA0820 | ECA4252 | Similar to Emericella nidulans O-acetyl-L-homoserine sulfhydrylase CysD SWALL:O13387 (EMBL:AF029318) (437 aa) fasta scores: E(): 2.6e-79, 52.47% id in 425 aa, and to Shewanella oneidensis O-acetylhomoserine so1095 SWALL:AAN54166 (EMBL:AE015554) (430 aa) fasta scores: E(): 3.2e-138, 85.21% id in 426 aa. | Similar to Escherichia coli cystathionine gamma-synthase MetB or b3939 SWALL:METB_ECOLI (SWALL:P00935) (386 aa) fasta scores: E(): 3.8e-129, 87.01% id in 385 aa. | 0.965 |
| ECA0820 | metF | ECA0820 | ECA4244 | Similar to Emericella nidulans O-acetyl-L-homoserine sulfhydrylase CysD SWALL:O13387 (EMBL:AF029318) (437 aa) fasta scores: E(): 2.6e-79, 52.47% id in 425 aa, and to Shewanella oneidensis O-acetylhomoserine so1095 SWALL:AAN54166 (EMBL:AE015554) (430 aa) fasta scores: E(): 3.2e-138, 85.21% id in 426 aa. | Similar to Erwinia carotovora 5,10-methylenetetrahydrofolate reductase MetF SWALL:METF_ERWCA (SWALL:P71319) (298 aa) fasta scores: E(): 4.2e-114, 97.65% id in 298 aa, and to Escherichia coli, and Shigella flexneri 5,10-methylenetetrahydrofolate reductase MetF or b3941 or sf4019 SWALL:METF_ECOLI (SWALL:P00394) (296 aa) fasta scores: E(): 2.1e-101, 86.05% id in 294 aa. | 0.474 |
| ECA0820 | metL | ECA0820 | ECA4251 | Similar to Emericella nidulans O-acetyl-L-homoserine sulfhydrylase CysD SWALL:O13387 (EMBL:AF029318) (437 aa) fasta scores: E(): 2.6e-79, 52.47% id in 425 aa, and to Shewanella oneidensis O-acetylhomoserine so1095 SWALL:AAN54166 (EMBL:AE015554) (430 aa) fasta scores: E(): 3.2e-138, 85.21% id in 426 aa. | Similar to Escherichia coli bifunctional aspartokinase/homoserine dehydrogenase II MetL or MetM or b3940 SWALL:AK2H_ECOLI (SWALL:P00562) (809 aa) fasta scores: E(): 0, 83.12% id in 800 aa; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.977 |
| ECA0820 | thrA | ECA0820 | ECA3891 | Similar to Emericella nidulans O-acetyl-L-homoserine sulfhydrylase CysD SWALL:O13387 (EMBL:AF029318) (437 aa) fasta scores: E(): 2.6e-79, 52.47% id in 425 aa, and to Shewanella oneidensis O-acetylhomoserine so1095 SWALL:AAN54166 (EMBL:AE015554) (430 aa) fasta scores: E(): 3.2e-138, 85.21% id in 426 aa. | Similar to Escherichia coli bifunctional aspartokinase/homoserine dehydrogenase I [includes: aspartokinase I; homoserine dehydrogenase I] thra or thra1 or thra2 or b0002 SWALL:AK1H_ECOLI (SWALL:P00561) (820 aa) fasta scores: E(): 0, 82.41% id in 819 aa; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.977 |
| ECA0820 | thrB | ECA0820 | ECA3890 | Similar to Emericella nidulans O-acetyl-L-homoserine sulfhydrylase CysD SWALL:O13387 (EMBL:AF029318) (437 aa) fasta scores: E(): 2.6e-79, 52.47% id in 425 aa, and to Shewanella oneidensis O-acetylhomoserine so1095 SWALL:AAN54166 (EMBL:AE015554) (430 aa) fasta scores: E(): 3.2e-138, 85.21% id in 426 aa. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.948 |
| ilvA | ECA0820 | ECA4225 | ECA0820 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Similar to Emericella nidulans O-acetyl-L-homoserine sulfhydrylase CysD SWALL:O13387 (EMBL:AF029318) (437 aa) fasta scores: E(): 2.6e-79, 52.47% id in 425 aa, and to Shewanella oneidensis O-acetylhomoserine so1095 SWALL:AAN54166 (EMBL:AE015554) (430 aa) fasta scores: E(): 3.2e-138, 85.21% id in 426 aa. | 0.945 |
| ilvA | metA | ECA4225 | ECA3992 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.947 |
| ilvA | metB | ECA4225 | ECA4252 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Similar to Escherichia coli cystathionine gamma-synthase MetB or b3939 SWALL:METB_ECOLI (SWALL:P00935) (386 aa) fasta scores: E(): 3.8e-129, 87.01% id in 385 aa. | 0.952 |
| ilvA | metL | ECA4225 | ECA4251 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Similar to Escherichia coli bifunctional aspartokinase/homoserine dehydrogenase II MetL or MetM or b3940 SWALL:AK2H_ECOLI (SWALL:P00562) (809 aa) fasta scores: E(): 0, 83.12% id in 800 aa; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.745 |
| ilvA | sdaA | ECA4225 | ECA2380 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | L-serine dehydratase 1; Similar to Escherichia coli L-serine dehydratase 1 SdaA or b1814 SWALL:SDHL_ECOLI (SWALL:P16095) (454 aa) fasta scores: E(): 5.1e-154, 83.92% id in 454 aa. Also similar to ECA3159 (SdaB) (75.165% id. in 455 aa overlap); Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.952 |
| ilvA | serB | ECA4225 | ECA0465 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Phosphoserine phosphatase; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri phosphoserine phosphatase SerB or b4388 or z5989 or ecs5346 or sf4420 SWALL:SERB_ECOLI (SWALL:P06862) (322 aa) fasta scores: E(): 5.7e-81, 71.87% id in 320 aa. | 0.945 |
| ilvA | thrA | ECA4225 | ECA3891 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Similar to Escherichia coli bifunctional aspartokinase/homoserine dehydrogenase I [includes: aspartokinase I; homoserine dehydrogenase I] thra or thra1 or thra2 or b0002 SWALL:AK1H_ECOLI (SWALL:P00561) (820 aa) fasta scores: E(): 0, 82.41% id in 819 aa; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.745 |
| ilvA | thrB | ECA4225 | ECA3890 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.549 |
| ilvA | trpB | ECA4225 | ECA2300 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.961 |
| metA | ECA0820 | ECA3992 | ECA0820 | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Similar to Emericella nidulans O-acetyl-L-homoserine sulfhydrylase CysD SWALL:O13387 (EMBL:AF029318) (437 aa) fasta scores: E(): 2.6e-79, 52.47% id in 425 aa, and to Shewanella oneidensis O-acetylhomoserine so1095 SWALL:AAN54166 (EMBL:AE015554) (430 aa) fasta scores: E(): 3.2e-138, 85.21% id in 426 aa. | 0.991 |
| metA | ilvA | ECA3992 | ECA4225 | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.947 |
| metA | metB | ECA3992 | ECA4252 | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Similar to Escherichia coli cystathionine gamma-synthase MetB or b3939 SWALL:METB_ECOLI (SWALL:P00935) (386 aa) fasta scores: E(): 3.8e-129, 87.01% id in 385 aa. | 0.989 |
| metA | metF | ECA3992 | ECA4244 | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Similar to Erwinia carotovora 5,10-methylenetetrahydrofolate reductase MetF SWALL:METF_ERWCA (SWALL:P71319) (298 aa) fasta scores: E(): 4.2e-114, 97.65% id in 298 aa, and to Escherichia coli, and Shigella flexneri 5,10-methylenetetrahydrofolate reductase MetF or b3941 or sf4019 SWALL:METF_ECOLI (SWALL:P00394) (296 aa) fasta scores: E(): 2.1e-101, 86.05% id in 294 aa. | 0.951 |
