| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| glnE | mscL | ECA3585 | ECA4003 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.482 |
| kefB | mscL | ECA4056 | ECA4003 | Glutathione-regulated potassium-efflux system protein; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.594 |
| kefB | trkA | ECA4056 | ECA4002 | Glutathione-regulated potassium-efflux system protein; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | Potassium uptake protein; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri Trk system potassium uptake protein TrkA or b3290 or c4050 or z4660 or ecs4155 or sf3321 SWALL:TRKA_ECOLI (SWALL:P23868) (458 aa) fasta scores: E(): 3.2e-140, 85.37% id in 458 aa. | 0.676 |
| menG | mscL | ECA4264 | ECA4003 | S-adenosylmethionine:2-demethylmenaquinone methyltransferase; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome. | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.542 |
| metK | mscL | ECA3920 | ECA4003 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.646 |
| metK | polA | ECA3920 | ECA0021 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Putative DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.587 |
| metK | recA | ECA3920 | ECA3369 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | RecA protein (recombinase A); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.624 |
| metK | ribH | ECA3920 | ECA1127 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.936 |
| metK | sun | ECA3920 | ECA4001 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.679 |
| mscL | glnE | ECA4003 | ECA3585 | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.482 |
| mscL | kefB | ECA4003 | ECA4056 | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | Glutathione-regulated potassium-efflux system protein; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. | 0.594 |
| mscL | menG | ECA4003 | ECA4264 | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | S-adenosylmethionine:2-demethylmenaquinone methyltransferase; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome. | 0.542 |
| mscL | metK | ECA4003 | ECA3920 | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.646 |
| mscL | pitA | ECA4003 | ECA0048 | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | Low-affinity inorganic phosphate transporter; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 low-affinity inorganic phosphate transporter 1 PitA or Pit or b3493 or c4291 or z4893 or ecs4365 SWALL:PITA_ECOLI (SWALL:P37308) (499 aa) fasta scores: E(): 1.3e-136, 70.37% id in 503 aa. | 0.555 |
| mscL | polA | ECA4003 | ECA0021 | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | Putative DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.524 |
| mscL | recA | ECA4003 | ECA3369 | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | RecA protein (recombinase A); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.520 |
| mscL | ribH | ECA4003 | ECA1127 | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.896 |
| mscL | sun | ECA4003 | ECA4001 | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.547 |
| mscL | trkA | ECA4003 | ECA4002 | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | Potassium uptake protein; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri Trk system potassium uptake protein TrkA or b3290 or c4050 or z4660 or ecs4155 or sf3321 SWALL:TRKA_ECOLI (SWALL:P23868) (458 aa) fasta scores: E(): 3.2e-140, 85.37% id in 458 aa. | 0.747 |
| pitA | mscL | ECA0048 | ECA4003 | Low-affinity inorganic phosphate transporter; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 low-affinity inorganic phosphate transporter 1 PitA or Pit or b3493 or c4291 or z4893 or ecs4365 SWALL:PITA_ECOLI (SWALL:P37308) (499 aa) fasta scores: E(): 1.3e-136, 70.37% id in 503 aa. | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.555 |
