STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pmrCPutative sulfatase; Similar to Pectobacterium carotovorum subsp. carotovorum putative cytoplasmic membrane protein PmrC pmrC SWALL:CAE47078 (EMBL:AJ583007) (548 aa) fasta scores: E(): 4.1e-202, 93.79% id in 548 aa, and to Escherichia coli hypothetical protein yjdb or b4114 SWALL:YJDB_ECOLI (SWALL:P30845) (547 aa) fasta scores: E(): 1.2e-128, 59.29% id in 538 aa. (548 aa)    
Predicted Functional Partners:
arnT
Dolichyl-phosphate-mannose-protein mannosyltransferase-family protein; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family.
  
 
 0.979
ECA0044
Similar to Yersinia pestis putative membrane protein ypo4013 SWALL:Q8ZA13 (EMBL:AJ414160) (563 aa) fasta scores: E(): 5e-173, 75.4% id in 557 aa, and to Escherichia coli membrane-protein YhjW SWALL:YHJW_ECOLI (SWALL:P37661) (563 aa) fasta scores: E(): 7.5e-150, 64.99% id in 557 aa.
  
  
0.965
pagP
Putative antimicrobial peptide resistance and lipid A acylation protein; Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors.
     
 0.959
lpxT
Putative membrane-bound phosphatase; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family.
     
 0.959
msbB
Lipid A biosynthesis (KDO)2-(lauroyl)-lipid iva acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A.
     
 0.952
pmrB
Two-component sensor kinase; Similar to Pectobacterium carotovorum subsp. carotovorum sensor kinase PmrB SWALL:CAE47080 (EMBL:AJ583007) (364 aa) fasta scores: E(): 1.5e-125, 94.78% id in 364 aa, and to Escherichia coli sensor protein BasS or PmrB or b4112 SWALL:BASS_ECOLI (SWALL:P30844) (363 aa) fasta scores: E(): 9.5e-69, 58.64% id in 353 aa.
  
  
 0.848
pmrA
Two-component response regulator; Similar to Pectobacterium carotovorum subsp. carotovorum response regulator PmrA SWALL:CAE47079 (EMBL:AJ583007) (222 aa) fasta scores: E(): 6.4e-85, 98.19% id in 222 aa, and to Escherichia coli transcriptional regulatory protein BasR or PmrA or b4113 SWALL:BASR_ECOLI (SWALL:P30843) (222 aa) fasta scores: E(): 1.4e-52, 60.63% id in 221 aa.
  
  
 0.817
dgkA
Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid.
 
   
 0.519
parC
Topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
   
  
 0.508
kdpB
Potassium-transporting ATPase B chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
   
    0.492
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.