STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ECA4061Similar to Yersinia pestis hypothetical protein ypo0179 or y3960 SWALL:AAM87504 (EMBL:AJ414141) (78 aa) fasta scores: E(): 1.1e-19, 73.97% id in 73 aa, and to Salmonella typhi hypothetical protein yheu or sty4334 SWALL:Q8Z1Z0 (EMBL:AL627281) (72 aa) fasta scores: E(): 1.2e-19, 77.14% id in 70 aa; Belongs to the UPF0270 family. (78 aa)    
Predicted Functional Partners:
ECA4060
Putative hydrolase; Similar to Yersinia pestis hypothetical protein ypo0180 or y3961 SWALL:AAM87505 (EMBL:AJ414141) (326 aa) fasta scores: E(): 1.3e-103, 73.31% id in 326 aa, and to Escherichia coli O157:H7 orf, hypothetical protein yhet or z4714 or ecs4204 SWALL:Q8X873 (EMBL:AE005558) (340 aa) fasta scores: E(): 3.5e-95, 69.27% id in 319 aa.
       0.801
prkB
Phosphoribulokinase; Similar to Alcaligenes eutrophus phosphoribulokinase, plasmid CfxP SWALL:KPPP_ALCEU (SWALL:P19924) (291 aa) fasta scores: E(): 6.8e-62, 56.69% id in 284 aa, and to Escherichia coli, and Shigella flexneri probable phosphoribulokinase PrkB or b3355 or sf3374 SWALL:KPPR_ECOLI (SWALL:P37307) (289 aa) fasta scores: E(): 8.9e-100, 86.15% id in 289 aa.
       0.560
ECA4059
Putative membrane protein; Similar to Yersinia pestis putative ABC-transport protein ypo0181 SWALL:Q8ZJD2 (EMBL:AJ414141) (200 aa) fasta scores: E(): 4.2e-65, 80.5% id in 200 aa, and to Shewanella oneidensis transporter, lyse family so1716 SWALL:AAN54770 (EMBL:AE015617) (197 aa) fasta scores: E(): 9e-24, 36.73% id in 196 aa.
       0.544
ttK
TetR-family transcriptional regulator; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
 
     0.512
thiI
Thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
     0.483
yihI
Conserved hypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family.
  
     0.461
rseA
sigma-E factor negative regulator; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases [...]
  
     0.440
ECA3777
Similar to Salmonella typhi hypothetical upf0231 protein yacl or sty0182 or t0165 SWALL:Q8Z9E5 (EMBL:AL627265) (120 aa) fasta scores: E(): 1.2e-33, 70.94% id in 117 aa, and to Escherichia coli O6 hypothetical upf0231 protein yacl or c0148 SWALL:AAN78642 (EMBL:AE016755) (136 aa) fasta scores: E(): 3.5e-32, 70.08% id in 117 aa.
  
     0.411
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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