STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
abrBPutative membrane protein; Similar to Escherichia coli AbrB protein AbrB or b0715 SWALL:ABRB_ECOLI (SWALL:P75747) (348 aa) fasta scores: E(): 4.8e-66, 51.91% id in 339 aa, and to Salmonella typhi putative membrane protein sty0772 SWALL:Q8Z8D1 (EMBL:AL627268) (348 aa) fasta scores: E(): 2.1e-67, 53.39% id in 339 aa. (352 aa)    
Predicted Functional Partners:
chpR
Suppressor of growth inhibitory protein ChpA; Similar to Escherichia coli, and Escherichia coli O157:H7 PemI-like protein 1 ChpR or MazE or ChpaI or b2783 or z4098 or ecs3643 SWALL:CHPR_ECOLI (SWALL:P18534) (82 aa) fasta scores: E(): 4.6e-09, 38.55% id in 83 aa, and to Bacillus halodurans suppressor of ppgpp-regulated growth inhibitor bh3720 SWALL:Q9K6K9 (EMBL:AP001519) (81 aa) fasta scores: E(): 6.1e-05, 38.75% id in 80 aa.
      
 0.625
mraZ
Conserved hypothetical protein; Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster.
      
 0.530
chpA
Putative growth inhibitory protein; Similar to Escherichia coli, and Escherichia coli O157:H7 PemK-like protein 1 ChpA or MazF or ChpaK or b2782 or z4097 or ecs3642 SWALL:CHPA_ECOLI (SWALL:P33645) (111 aa) fasta scores: E(): 5.2e-31, 72.97% id in 111 aa, and to Deinococcus radiodurans ppgpp-regulated growth inhibitor chpa/mazf, putative dr0417 SWALL:Q9RX98 (EMBL:AE001901) (117 aa) fasta scores: E(): 5e-18, 48.21% id in 112 aa.
      
 0.524
parE
Topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
      
 0.470
relA
GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
      
 0.469
slyD
FkbP-type peptidyl-prolyl cis-trans isomerase; Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri FkbP-type peptidyl-prolyl cis-trans isomerase SlyD or b3349 or c4123 or z4707 or ecs4200 or sf3367 SWALL:SLYD_ECOLI (SWALL:P30856) (196 aa) fasta scores: E(): 1.3e-60, 84.92% id in 199 aa.
      
 0.461
qseC
Two-component system sensor kinase; Similar to Escherichia coli sensor protein QseC SWALL:QSEC_ECOLI (SWALL:P40719) (449 aa) fasta scores: E(): 7.4e-94, 56.15% id in 447 aa.
  
     0.456
waaL1
O-antigen ligase; Similar to Escherichia coli O-antigen ligase RfaL or WaaL or b3622 SWALL:RFAL_ECOLI (SWALL:P27243) (419 aa) fasta scores: E(): 1.2e-28, 29.22% id in 414 aa, and to Serratia marcescens lipid a core:surface polymer ligase WaaL SWALL:Q936B4 (EMBL:U52844) (413 aa) fasta scores: E(): 1.1e-39, 33.76% id in 385 aa. Also similar to ECA0161 (36.735% id. in 392 aa overlap).
  
     0.447
corA
Magnesium and cobalt transport protein; Mediates influx of magnesium ions. Can also mediate cobalt and manganese uptake (By similarity). Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high (By similarity). Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
       0.432
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
      
 0.415
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.