STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ECA4180Putative hydrolase; Similar to Escherichia coli, and Shigella flexneri hypothetical protein yigb or b3812 or sf3890 SWALL:YIGB_ECOLI (SWALL:P23306) (238 aa) fasta scores: E(): 1.4e-60, 66.8% id in 238 aa, and to Yersinia pestis putative haloacid dehalogenase-like hydrolase ypo3842 or y0388 SWALL:Q8ZAG0 (EMBL:AJ414159) (238 aa) fasta scores: E(): 3.4e-60, 66.38% id in 238 aa. (238 aa)    
Predicted Functional Partners:
ribD
Riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
    
 0.942
ribF
Similar to Escherichia coli, Escherichia coli O6, Escherichia coli O157:H7, and Shigella flexneri riboflavin biosynthesis protein ribf [includes: riboflavin kinase; FMN adenylyltransferase] RibF or b0025 or c0029 or z0029 or ecs0028 or sf0021 SWALL:RIBF_ECOLI (SWALL:P08391) (313 aa) fasta scores: E(): 2.3e-89, 76.03% id in 313 aa.
  
 
 0.912
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family.
     
 0.906
ECA1923
Riboflavin synthase alpha chain; Similar to Escherichia coli, and Shigella flexneri riboflavin synthase alpha chain RibE or RibC or b1662 or sf1690 SWALL:RISA_ECOLI (SWALL:P29015) (213 aa) fasta scores: E(): 7e-61, 76.84% id in 203 aa.
   
 
 0.903
fre
NAD(P)H-flavin reductase; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 NAD(P)H-flavin reductase Fre or FlrD or FadI or FsrC or UbiB or b3844 or c4791 or z5365 or ecs4772 SWALL:FRE_ECOLI (SWALL:P23486) (232 aa) fasta scores: E(): 5.8e-71, 75.86% id in 232 aa.
  
 
  0.900
ECA0351
Probable nitroreductase; Similar to Bacillus subtilis nitro/flavin reductase NfrA or NfrA1 or Ipa-43D SWALL:NFRA_BACSU (SWALL:P39605) (249 aa) fasta scores: E(): 5.2e-19, 29.83% id in 248 aa, and to Clostridium acetobutylicum ortholog ycnd b.subtilis, nitroreductase cac0718 SWALL:Q97L47 (EMBL:AE007587) (246 aa) fasta scores: E(): 1.2e-42, 45.49% id in 244 aa; Belongs to the flavin oxidoreductase frp family.
     
  0.900
ECA4198
Putative exported phosphatase; Similar to Pseudomonas syringae phytase PhyM SWALL:AAN77879 (EMBL:AY156083) (428 aa) fasta scores: E(): 3.4e-77, 48.73% id in 433 aa, and to Escherichia coli glucose-1-phosphatase precursor Agp or b1002 SWALL:AGP_ECOLI (SWALL:P19926) (413 aa) fasta scores: E(): 1.5e-31, 31.08% id in 415 aa.
     
  0.900
xerC
Integrase/recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerC specifically exchanges the t [...]
  
    0.827
ECA4182
Similar to Yersinia pestis hypothetical protein ypo3844 or y0386 SWALL:Q8ZAF8 (EMBL:AJ414159) (234 aa) fasta scores: E(): 1.8e-68, 73.93% id in 234 aa, and to Salmonella typhi hypothetical protein Sty3611 SWALL:Q8Z3A7 (EMBL:AL627279) (235 aa) fasta scores: E(): 4.6e-60, 64.68% id in 235 aa.
  
    0.825
dapF
Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.
       0.801
Your Current Organism:
Pectobacterium atrosepticum
NCBI taxonomy Id: 218491
Other names: Erwinia carotovora subsp. atroseptica SCRI1043, Erwinia carotovora subsp. atroseptica str. SCRI1043, P. atrosepticum SCRI1043, Pectobacterium atrosepticum SCRI1043, Pectobacterium atrosepticum str. SCRI1043, Pectobacterium atrosepticum strain SCRI1043, Pectobacterium carotovora subsp. atroseptica SCRI1043, Pectobacterium carotovora subsp. atroseptica str. SCRI1043
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